抗癫痫药物引发药疹的发病机制  

Pathogenesis of Antiepileptics-Induced Drug Eruption

作　　者：吴培培[1] 李奕[1] 乔海灵[1] 杨静[1] 

机构地区：[1]郑州大学临床药理研究所,郑州450052

出　　处：《中华临床免疫和变态反应杂志》2013年第1期72-78,共7页Chinese Journal of Allergy & Clinical Immunology

基　　金：河南省科技创新杰出青年基金(104100510008);河南省青年骨干教师基金(2012)

摘　　要：抗癫痫类药物是临床引发药疹的常见药物之一,其中重症药疹(Stevens-Johnson综合征、中毒性表皮坏死松解症)的发病率最高。近年来的研究显示人类白细胞抗原基因的多态性、相关免疫细胞和分泌的细胞因子、自身的分子结构和化学反应性、以及病毒感染等多种因素影响其发病。目前随着药疹基因水平的深入研究,用药前筛查致敏基因将成为一种新型的预防手段。Antiepileptics is one of the most common allergenic medications that can induce various forms of drug eruption, and severe drug eruptions including Stevens-Johnson syndrome and Toxic Epidermal Necrolysis are the most predominant form in clinical practice. The results of recent studies show that the polymorphisms of HLA genes, immune cells, cytokines, molecular structure and chemical reactivity of antiepileptics, virus infections etc play important roles in the pathogenesis of antiepilepticinduced drug eruption. Based on the progress in the field of drug eruption related genes, screening of allergenic genes before administration will become a new preventive method of severe adverse drug reactions.

关 键 词：抗癫痫药 药疹 发病机制 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]