RFA和TACE联合应用对原发性肝癌的疗效分析  

Clinical investigation of RFA and TACE combined in the therapy of PHC

作　　者：李陆平[1] 李森[2] 

机构地区：[1]潍坊医学院,山东潍坊261000 [2]潍坊市人民医院

出　　处：《青岛医药卫生》2013年第2期88-90,共3页Qingdao Medical Journal

摘　　要：目的通过回顾性研究比较经非手术治疗包括经导管肝动脉化疗药物栓塞术(TA-CE)、肝脏肿瘤射频消融术(RFA)以及RFA和TACE联合治疗后肝癌患者的远期生存率,来探讨联合RFA和TACE治疗在无法耐受根治性手术治疗的原发性肝癌患者治疗中的优势。方法选取我院2008年1月至2009年10月的40例原发性肝癌患者作为研究对象。本研究中所有病人均在非手术治疗操作前行肝组织学穿刺活检术,术后病理证实均为肝细胞肝癌,通过影像学检查(强化CT或强化MRI),均未发现肝外等远处其他脏器转移,均无手术适应证。40例肝癌患者中接受RFA治疗者10例(RFA组),TACE治疗者20例(TACE组),RFA和TACE联合治疗者10例(联合组)。结果 1年生存率联合组和RFA组显著高于TACE组(P<0.05),RFA组和联合组无显著性差异(P>0.05)。2年生存率联合组显著高于TACE组和RFA组(P<0.05),而后两者无显著性差异(P>0.05)。3年生存率联合组显著高于TACE组及RFA组(P<0.05),而RFA组与TACE组无显著性差异(P>0.05)。结论在原发性肝癌非手术治疗方法的选择中,RFA和TACE联合治疗是一种有效的治疗方法,比TACE或RFA治疗方法更具有优势,此法更能提高患者的远期生存率,更具有临床应用价值。Objective Using the retrospective analysis to compare the long term survival rate of patients with liver cancer after non-surgical treatment （TACE, RFA, RFA and TACE treatment）, to explore the advantages of joint RFA and TACE therapy in the treatment of prima- ry liver cancer in patients unable to tolerate radical surgical treatment. Methods 40 patients with primary liver cancer were taken as a clinical study from January 2008 to October 2009 in our hospital. All patients in this study were in the non-surgical treatment before liver histology nee- dle biopsy, postoperative pathology were hepatocellular carcinoma, the extrahepatic and other or- gans in the distance metastasis were not found by imaging studies （enhanced CT or enhanced MRI） ,there was no surgical indications. 10 cases of 40 liver cancer patients accepted RFA treat- ment （RFA group）, 20 cases accepted TACE treatment（TACE group）,and 10 cases accepted RFA and TACE combined treatment （the combined group）. Results The 1-year survival rate of combined group and the RFA group was significantly higher than the TACE group （P〈0.05）, there was no significant difference between RFA group and the combined group. The 2-year sur- vival rate of the combination group was significantly higher than the TACE group and the RFA group （P〈0.05）, and there was no significant difference between the latter two （P〈0.05）. The 3-year survival rate of the combined group was significantly higher than the TACEgroup and the RFA group （P〈 0.05）, and there was no significant difference between RFA group and the TACE group（P〉0.05）. Conclusion For clinicians, RFA and TACE combined therapy is an effective treatment method better than TACE or RFA treatment in the selection of liver cancer non-surgical treatment. This method is good to extend the long term survival time of patients.

关 键 词：原发性肝癌 经超声引导下肝脏肿瘤射频消融术 经导管肝动脉化疗药物栓塞术 

分 类 号：R657.3[医药卫生—外科学]