A new anti-hypoxia functional agent ——Schizophyllum commune fermented broth and its biochemical mechanisms  

作　　者：Hao Limin Lu Jike Wu Tianyi Ba Jianming Guo Changjiang Qian Ping Yu Jianyong Xing Xinhui 

机构地区：[1]The Quartermaster Equipment Institute of GLD of CPLA [2]Department of Bioengineering,Zhengzhou University [3]High Altitude Medical Research Institute [4]Department of Endocrinology,Chinese PLA General Hospital [5]Institute of Hygiene and Environmental Medicine, Academy of Military Medical Sciences [6]Department of Chemical Engineering and Technology,Tsinghua University

出　　处：《Engineering Sciences》2013年第2期82-87,共6页中国工程科学（英文版）

基　　金：National Nature Science Foundation of China(No.31171662);"973"National Key Basic Research and Development Program(No.2012CB518202);Project of Qinghai Development of Science and Technology(No.2011-N-150)

摘　　要：In order to overcome hypoxia induced sickness, a stable source of anti-hypoxia functional agents, Sehizophyllum commune fermented broth has been developed in this study. Animal experiments were conducted to examine its anti-hypoxia activities and possible mechanisms involved. The acute hypoxic experiment showed that Sehizophyllum commune fermented broth could significantly prolong the survival time of mice. The underlying mechanisms were associated with improved energy metabolism based on a study carried out in rats exposed to a low pressure chamber simulating the low pressure environment of 8 000 m altitude. It was concluded that the Schizophyllum commune fermented broth was an effective anti-hypoxia functional agent and could be greatly bene- ficial to those living and working at high altitudes, such as people who reside in the reconstruction regions of Yushu.

关 键 词：altitude illness prevention and treatment ANTI-HYPOXIA aerobic metabolism GLYCOGEN adenosinetriphosphate （ATP） 

分 类 号：S435.622.3[农业科学—农业昆虫与害虫防治] TS225.19[农业科学—植物保护]