雷贝拉唑或艾美拉唑为基础的三联治疗方案根除幽门螺杆菌感染的疗效比较  

The effects of the triple treatment for helicobacter pylori infection with rabeprazole or esomeprazole

作　　者：秦霞[1] 范传文[2] 刘红[1] 郭红彦[1] 

机构地区：[1]淮南联合大学化工系,安徽淮南232038 [2]扬子江药业集团,江苏泰州225321

出　　处：《蚌埠医学院学报》2013年第3期278-279,282,共3页Journal of Bengbu Medical College

基　　金：淮南联合大学校级科研项目(LYB1007)

摘　　要：目的:比较以雷贝拉唑或艾美拉唑为基础的三联治疗方案根除幽门螺杆菌(Helicobacter pylori,Hp)感染的安全性和有效性。方法:随机抽取381例Hp感染患者分为2组,A组190例,使用艾美拉唑40 mg每天1次,阿莫西林1 g每天2次,克拉霉素500 mg每天2次,疗程7 d;B组191例,使用雷贝拉唑20 mg每天2次,阿莫西林和克拉霉素的用法及疗程同A组。完成治疗后12～16周胃镜随访。拒绝胃镜检查的患者使用14C-呼气试验判断治疗效果。结果:A组根除Hp 170例,根除率为89.5%;B组根除173例,根除率为90.6%,差异无统计学意义(P>0.05)。A组不良反应发生率为4.21%,B组为6.81%,差异无统计学意义(P>0.05)。结论:以雷贝拉唑或艾美拉唑为基础的三联治疗方案根除Hp感染均有较好的安全性和有效性。Objective：To compare the efficacy and safety of the triple treatmentyes helicobacter pylori（Hp） infection with rabeprazole and esomeprazole.Methods：Three hundred and eighty-one cases with Hp infected were randomly divided into group A（190 cases）and group B（191 cases）,group A were treated with 40 mg of esomeprazole Once a day,1 g of amoxicillin 2 times a day,500 mg of clarithromycin 2 times a day for 7 days.Group B（191 cases） were treated with 20 mg of rabeprazole 2 times a day and the same amoxicillin and clarithromycin as group A.The effects of all cases were followed-up 12-16 weeks by gastroscope and 14C-urea breath test for rejecting gastroscope.Results：The eradication rates of group A were 89.5%（170 cases）and 90.6%（173 cases） in group B,the incidence of adverse reactions of group A were 4.21% and 6.81% in group B,which had no statistical significance（P0.05）.Conclusions：The triple treatment Hp infection with rabeprazole and esomeprazole are efficacy and safety.

关 键 词：幽门螺杆菌 雷贝拉唑 艾美拉唑 

分 类 号：R377[医药卫生—病原生物学]