Chiral Sulfinamide-Olefin Ligands： Switchable Selectivity in Rhodium-Catalyzed Asymmetric 1,2-Addition of Arylboronic Acids to Aliphatic α-Ketoesters  

作　　者：Ting-Shun Zhu Ming-Hua Xu 

机构地区：[1]Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

出　　处：《Chinese Journal of Chemistry》2013年第3期321-328,共8页中国化学（英文版）

基　　金：Financial support from the National Natural Science Foundation of China

摘　　要：Simple and readily available chiral N-（sulfinyl）allylamines have been developed as efficient novel ligands for the rhodium-catalyzed enantioselective 1,2-addition of arylboronic acids to challenging aliphatic a-ketoesters. By employing the linear or branched sulfinamide-olefin ligands, interesting enantioselectivity as well as regioselectiw ity reversal in the related asymmetric additions were observed.Simple and readily available chiral N-（sulfinyl）allylamines have been developed as efficient novel ligands for the rhodium-catalyzed enantioselective 1,2-addition of arylboronic acids to challenging aliphatic a-ketoesters. By employing the linear or branched sulfinamide-olefin ligands, interesting enantioselectivity as well as regioselectiw ity reversal in the related asymmetric additions were observed.

关 键 词：asymmetric catalysis rhodium sulfur-o｜efin ligand 1 2-addition stereoselectivity reversal 

分 类 号：O643.36[理学—物理化学] TQ572.3[理学—化学]