Preparation of Polymer-Functionalized Iron Oxide Nanoparti-cles and Their Biomedical Properties  

作　　者：Qing Lu Daixu Wei Juan Zhou Jianrong Xu Jiejun Cheng Jun Zhu 

机构地区：[1]Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China [2]National Engineering Research Center for Nanotechnology, Shanghai 200241, China

出　　处：《Chinese Journal of Chemistry》2013年第3期401-406,共6页中国化学（英文版）

基　　金：The authors are grateful to the financial supports from National Natural Science Foundation of China （30970819）, Shanghai Science and Technology Com-mittee （09XD1402900）, and Shanghai Leading Aca-demic Discipline Project （S30203）.

摘　　要：Superparamagnetic iron oxide nanoparticles with narrow size distributions were successfully prepared in large scale by a facile one-pot synthetic method in the presence of hydrophilic polymers, such as polyethylene glycol dia-cid （HOOC-PEG-COOH） and poly（acrylic acid） （PAA）. The as-prepared products were investigated in detail by powder X-ray diffraction （XRD）, thermogravimetric analyses （TGA）, transmission electron microscopy （TEM）, high-resolution transmission electron microscopy （HRTEM）, dynamic light scattering （DLS）, and vibrating sample magnetometer （VSM）. The interaction between polymers and iron oxide nanoparticles was investigated using Fou-rier transform infrared spectrometry （FT-IR）. The results show that polymers can be attached onto the surface of iron oxide nanoparticle by bridging coordination and monodentate fashion, respectively. The interaction affects iron oxide nanoparticle properties significantly, such as XRD diffraction intensity, hydrodynamic diameter, isoelectric point, and saturation magnetization. Furthermore, the results of in vitro experiments indicated that iron oxide-PEG-COOH nanoparticle is more cytotoxie than iron oxide-PAA nanoparticle due to different coordinating modes.Superparamagnetic iron oxide nanoparticles with narrow size distributions were successfully prepared in large scale by a facile one-pot synthetic method in the presence of hydrophilic polymers, such as polyethylene glycol dia-cid （HOOC-PEG-COOH） and poly（acrylic acid） （PAA）. The as-prepared products were investigated in detail by powder X-ray diffraction （XRD）, thermogravimetric analyses （TGA）, transmission electron microscopy （TEM）, high-resolution transmission electron microscopy （HRTEM）, dynamic light scattering （DLS）, and vibrating sample magnetometer （VSM）. The interaction between polymers and iron oxide nanoparticles was investigated using Fou-rier transform infrared spectrometry （FT-IR）. The results show that polymers can be attached onto the surface of iron oxide nanoparticle by bridging coordination and monodentate fashion, respectively. The interaction affects iron oxide nanoparticle properties significantly, such as XRD diffraction intensity, hydrodynamic diameter, isoelectric point, and saturation magnetization. Furthermore, the results of in vitro experiments indicated that iron oxide-PEG-COOH nanoparticle is more cytotoxie than iron oxide-PAA nanoparticle due to different coordinating modes.

关 键 词：superparamagnetic nanoparticle FUNCTIONALISATION coordinating mode cell cytotoxicity 

分 类 号：O621.3[理学—有机化学] Q95-33[理学—化学]