Syntheses, Supramolecular Structures and Antibacterial Activities of Five Helical Transition Complexes with 5-Chloro-1-phenyl-1 H-pyrazole-3,4-dicarboxylic Acid  

作　　者：Hong Liu Chongbo Liu Yunnan Gong Yuhua Wang Huiliang Wen 

机构地区：[1]Key Laboratory of Jiangxi Province for Ecological Diagnosis-Remediation and Pollution Control, Nanchang Hang Kong University, Nanchang, Jiangxi 330063, China [2]School of Environment and Chemical Engineering, Nanchang Hang Kong University, Nanchang, Jiangxi 330063, China [3]State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, China

出　　处：《Chinese Journal of Chemistry》2013年第3期407-414,共8页中国化学（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China （Nos. 20961007 and 21264011）, the Aviation Fund （No. 2010ZF56023） and the Young Scientists Program of Jiangxi Province （No. 2008DQ00600）.

摘　　要：Five new transition metal complexes [Cu（HL）2（H20）2] （1）, [Cu（HL）z（phen）] （2）, [Cu（HL）2（H20）]2（4,4′-bipy） （3）, [Zn（HL）2（HzO）2].（4,4′-bipy） （4）, [Ag（HL）（4,4′-bipy）]n （5）, （H2L=5-chloro-l-phenyl-lH-pyrazole-3,4-dicarboxylic acid, phen=1,10-phenanthroline; 4,4′-bipy = 4,4′bipyridine） have been synthesized and characterized. Complexes 1, 2 and 4 exhibit monomeric structures, 3 shows a dinuclear structure, 5 displays 1D chain structure, and all extend to 3D supramolecular network via rich hydrogen bonds. Complexes 1, 2, 3, 5 comprise single helical chains, while complex 4 generates quadruple-stranded helical chains. Furthermore, the antibacterial activities of the titled complexes against bacterial species, three Gram positive bacteria （Staphylococcus aureus, Bacillus subtilis and Candida albicans） and two Gram negative bacteria （Escherichia coli and Pseudomonas aeruginosa） were stud-ied and compared to the activities of free ligands by using the microdilution method.Five new transition metal complexes [Cu（HL）2（H20）2] （1）, [Cu（HL）z（phen）] （2）, [Cu（HL）2（H20）]2（4,4′-bipy） （3）, [Zn（HL）2（HzO）2].（4,4′-bipy） （4）, [Ag（HL）（4,4′-bipy）]n （5）, （H2L=5-chloro-l-phenyl-lH-pyrazole-3,4-dicarboxylic acid, phen=1,10-phenanthroline; 4,4′-bipy = 4,4′bipyridine） have been synthesized and characterized. Complexes 1, 2 and 4 exhibit monomeric structures, 3 shows a dinuclear structure, 5 displays 1D chain structure, and all extend to 3D supramolecular network via rich hydrogen bonds. Complexes 1, 2, 3, 5 comprise single helical chains, while complex 4 generates quadruple-stranded helical chains. Furthermore, the antibacterial activities of the titled complexes against bacterial species, three Gram positive bacteria （Staphylococcus aureus, Bacillus subtilis and Candida albicans） and two Gram negative bacteria （Escherichia coli and Pseudomonas aeruginosa） were stud-ied and compared to the activities of free ligands by using the microdilution method.

关 键 词：helix transition metal complexes pyrazole carboxylic acid N-donor co-ligands antibacterial activity 

分 类 号：O631.24[理学—高分子化学] S859.796[理学—化学]