过敏性紫癜肾损伤儿童血清胱抑素C、尿N-乙酰-β-D-氨基葡萄糖苷酶水平变化及其意义  

The change of the serum level of cystatin C, urinary NAG enzyme in the children affected by HSP and its clirical significale

作　　者：刘伟华[1] 杨宾 张北宁[1] 亢秋芳 

机构地区：[1]西安市第一医院儿科,陕西省西安710002 [2]西安市长安区妇幼医院儿科

出　　处：《中国基层医药》2013年第7期966-968,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：陕西省西安市卫生局基金项目（J2010806）

摘　　要：目的研究血清胱抑素C、尿N-乙酰-β-D-氨基葡萄糖苷酶（NAG）水平在小儿过敏性紫癜（HSP）肾损伤中的变化及临床意义。方法60例过敏性紫癜患儿按照尿常规和生化检查结果异常程度分为肾损A组、肾损B组、非肾损组；同龄健康人28例为对照组。采用酶联免疫双抗夹心法检测血清胱抑素C和尿NAG酶。结果尿NAG酶水平：肾损A组（127．11±15．63）ng／L、肾损B组（132．75±19．83）ng/L，均高于非肾损组的（111．36±20．10）ng／L（F=7．324，P〈0．05）；而非肾损组与对照组（108．14±13．83）ng／L差异无统计学意义。血清胱抑素C水平：肾损A组（1．18±0．13）mg／L、肾损B组（1．19±0．17）mg／L、非肾损组（1．16±0．11）mg／L，均显著高于对照组的（0．79±0．14）mg／L（P〈0．05）。结论尿NAG酶、血清胱抑素C可反映HSP患儿肾脏损害程度，联合检测可以作为小儿HSP肾脏损伤的早期、灵敏诊断指标。Objective To investigate the change of the serum levels of cystatin C,urinary NAG enzyme in the children affected by HSP and its cliracal significance. Methods 60 children with HSP were divided into three groups based on urine routine and abnormal degrees of biochemical examination results, which were kidney injury group A（ KI-Group A）, kidney injury group B （KI-Group B ）, and non-kidney injury group （non-KI-Group）. Selected 28 healthy children with the same phase and the same age as the control group. A sandwich enzyme-linked immuuosor- bent assay（ELISA） was employed to determine the values of cystatin C,urinary NAG enzyme. Results Urinary NAG enzyme in KI-Group A （ 127.11 ±15.63 ） ng/L and KI-Group B （ 132.75 ±19.83 ） ng/L were significantly higher than the control group （ 111.36 ± 20. 10 ） ng/L （ F = 7. 324, P 〈 0.05 ）, and there was no difference between non-KI-Group （108.14± 13. 83）ng/L and the control group. Cystatin C in KI-Group A （1.18 ± 0. 13 ）mg/L, KI- Group B （1.19±0.17 ）mg/L and non-KI-Group （1.16±0.11 ）mg/L were all significantly higher than the eontrol group （0.79 ±0.14）mg/L （P 〈 0. 05 ）. Conclusion Cystatin C and uri/aary NAG enzyme in children with HSP were significantly abnormal, and may be used as early indexes reflecting tlae glomerular injury. The relationship of the two above indicators had positive correlation, and the combined employment of them had the dadvantages of early de- tection, high sensitivity and accurate diat, nosis.

关 键 词：紫癜 过敏性 肾功能不全 胱抑素C 乙酰氨基葡糖苷酶 

分 类 号：R725.5[医药卫生—儿科]