阿托伐他汀对脓毒症大鼠肺损伤的保护作用  

Protective effect of atorvastatin against lung injury in septic rats

作　　者：于丹[1] 杨宇平[2] 钟强[3] 沈威[4] 

机构地区：[1]郑州大学人民医院重症医学科,河南郑州450003 [2]新乡医学院药学院药理学教研室,河南新乡453003 [3]华中科技大学同济医学院附属同济医院重症医学科,湖北武汉430030 [4]孝感市中心医院重症医学科,湖北孝感432100

出　　处：《新乡医学院学报》2013年第4期262-265,共4页Journal of Xinxiang Medical University

摘　　要：目的探讨阿托伐他汀对脓毒症大鼠肺损伤的保护作用。方法 60只大鼠随机分为假手术组、脓毒症组和干预组,每组20只。采用盲肠结扎穿孔(CLP)脓毒症大鼠模型,干预组分别于术后6、18 h腹腔注射阿托伐他汀(0.2 mg.kg-1),假手术组和脓毒症组同时间点给予等体积温生理盐水腹腔注射。观察各组大鼠术后20 h肺组织病理学改变、肺组织中超氧化物歧化酶(SOD)活性和丙二醛(MDA)水平及术后7 d生存率。结果与脓毒症组比较,干预组大鼠术后7 d生存率显著提高,病理示肺损伤明显减轻,肺组织SOD活性显著升高(P<0.01),而MDA水平显著降低(P<0.01)。干预组SOD活性及MDA水平与假手术组比较差异均有统计学意义(P<0.01)。结论阿托伐他汀可显著提高脓毒症大鼠的生存率,并可能通过减少肺氧自由基的产生,减轻肺损伤。Objective To investigate the protective effect of atorvastatin against lung injury in septic rats.Methods Sixty rats were randomly divided into sham operation group,sepsis group and intervention group with 20 rats in each group.Cecal ligation and puncture（CLP）method was used to establish the model.Rats in intervention group were treated twice by intraperitoneal injection of atorvastatin（0.2 mg·kg-1 body weight）after CLP 6 and 18 hours,while rats in sham operation group and sepsis group were treated with warm physiological saline of the same volome at the same time point.The lung histopathological changes,activity of superoxide dismutase（SOD）and content of malondialdehyde（MDA）in lung tissue 20 hours later,and 7-day survival rate after the operation were observed.Results In intervention group,7-day survival rats after the operation increased significantly,the lung injury improved distinguishedly,the activity of SOD increased significantly（P〈0.01）and the content of MDA decreased significantly（P〈0.01）compared with the sepsis group.There were significant differences of the activity of SOD and the content of MDA between intervention group and sham operation group（P〈0.01）.Conclusion The survival rates of septic rats can be improved by atorvastatin significantly and the lung injury can be inhibited by reducing oxidative stress in lung.

关 键 词：阿托伐他汀 脓毒症 超氧化物歧化酶 急性肺损伤 生存率 

分 类 号：R965[医药卫生—药理学]