铜绿假单胞菌对碳青霉烯类抗生素耐药率分析  

Resistance Change of Pseudomonas Aeruginosa to Carbapenems

作　　者：熊劲芝[1] 黄强[1] 张林[1] 刘巧突[1] 

机构地区：[1]湖南省郴州市第一人民医院检验中心微生物室,423000

出　　处：《医学理论与实践》2013年第7期843-844,846,共3页The Journal of Medical Theory and Practice

基　　金：郴州市第一人民医院科研项目(N2011-027)

摘　　要：目的:探讨临床分离的铜绿假单胞菌(PA)对碳青霉烯类抗生素的耐药率及其变迁情况,为临床治疗PA感染提供参考依据。方法:收集我院2006-2011年临床分离的2 521株PA用碳青霉烯类抗生素对其进行药敏实验。结果:PA感染以下呼吸道为主,主要分布在重症监护病房(48.79%)。耐药性、多重耐药性和泛耐药PA的分离率逐年上升,其耐药率也逐年上升。PA对亚胺培南6年总平均耐药率分别为21.07%;PA 2006年对亚胺培南的耐药率为2.34%,2011年上升到41.98%。结论:PA对碳青霉烯类抗生素的耐药性呈明显上升趋势,临床应适当控制碳青霉烯类药物的使用,以有效控制及延缓耐药株的产生。Objective：To investigate the change of resistance of Pseudomonas aeruginosa （PA） to Carbapenems inhospital so as to guide clinic treatment of PA infection. Methods. Drug sensitivity tests of 2 521 PA strains clinically isolated during 2006 to 2011 were made for Carbapenems. Results： The common site infected by PA was lower respiratory tract and the main department was ICU （48. 79 %）. The isolation rates of PA with drug resistance, multi-drug resistance and pan-resistant strains increased steadily in recent years, and so did their drug resistance rates. The average resistance rate of Imipenem was 29. 2%. In 2006, the resistant rate of Imipenem was 2. 34%, while it increased to 41.98% in 2011 （P〈0. 05）. Conclusion：The resistance rate of PA to Carbapenems is obviously increasing, in order to control and slow down the occurrence of the resistant strains, the clinical usage of the Carbapenems should be strategically controlled.

关 键 词：铜绿假单胞菌 碳青霉烯类抗生素 耐药性 

分 类 号：R978.1[医药卫生—药品]