乙肝父婴垂直传播的临床观察  

Clinical observation on vertical transmission from HBsAg-positive fathers to infants

作　　者：陈起燕[1] 张荣莲[1] 黄欣欣[1] 修晓燕[1] 任坤海[1] 王梅颖[1] 

机构地区：[1]福建医科大学福建省妇幼保健院教学医院,350001

出　　处：《中国妇幼保健》2013年第11期1747-1748,共2页Maternal and Child Health Care of China

基　　金：福建省自然科学基金项目〔2011J01124〕;福建省医学创新课题〔2011-cxb-17〕

摘　　要：目的:探讨父亲单方为乙肝病毒(HBV)感染者对子代的影响。方法:对父亲HBsAg阳性,母亲血清HBVM及HBVDNA均为阴性的306个家庭进行父亲血清HBeAg阳性状态、父亲血清HBV-DNA病毒载量、父亲精液HBV-DNA载量及新生儿脐带血HBV-DNA进行临床观察。结果:父亲肝功能异常发生率为7.5%;新生儿HBV感染率为21.6%(66/306);病例组中父亲为HBeAg阳性者达81.8%、血液HBV DNA阳性者达100%、精液HBV DNA阳性者达54.2%,分别是阴性者中发生HBV父婴垂直传播的8.7倍、2.1倍和34.3倍。结论:临床观察结果表明,孕前保健中务必将准父亲的血清HBeAg、HBVDNA、精液HBV DNA列入男性HBsAg阳性者的检测常规,对阳性者进行必要的系统有效的抗病毒治疗将对防范乙肝父婴垂直传播起积极和有效的作用。Objective： To explore the effect of paternal hepatitis B virus （HBV） infection on infants. Methods ： The positive sta- tus of serum HBeAg, paternal serum HBV DNA load, paternal spermie HBV DNA load, and neonatal umbilical cord blood HBV DNA were observed among 306 families with HBsAg - positive fathers, serum negative - HBVM and negative - HBVDNA mothers. Results： The inci- dence rates of paternal liver dysfunction was 7. 5% ; the incidence rate of HBV infection among neonates was 21.6% （66/306） ; in case group, 81.8% of fathers were found with positive HBeAg, the positive rates of blood HBV DNA and spermic HBV DNA were 100% and 54. 2%, respectively, which were 8. 7, 2. 1, and 34. 3 times more than those among HBsAg - negative fathers. Conclusion ： Paternal serum HBeAg, HBV DNA, and spermie HBV DNA detections should be included into conventional detection of men with positive HBsAg during antenatal care ; necessary, systematic, and effective antiviral therapy among the patients with positive results may play an active and effective role in prevention of vertical transmission from HBsAg - positive fathers to infants.

关 键 词：乙型肝炎病毒 父婴传播 临床观察 

分 类 号：R512.6[医药卫生—内科学]