抗苗勒氏管激素与多囊卵巢综合征结局的关系  

Relationship between anti-müllerian hormone and outcome of polycystic ovary syndrome

作　　者：彭宇洪[1] 王彬[1] 陈丽梅[1] 钟树怀[1] 伍玉燕[1] 

机构地区：[1]广东省东莞市人民医院,523000

出　　处：《中国妇幼保健》2013年第11期1769-1771,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨多囊卵巢综合征(PCOS)患者AMH对促排卵过程中外源性促性腺激素剂量的影响,评估AMH对促排卵治疗结局的影响。方法:检测123例PCOS患者基础AMH和性激素水平,根据AMH水平分为A组42例,B组36例,C组45例。患者接受尿促性素促排卵,比较各组尿促性素的剂量和治疗结局。结果:A组尿促性素首剂量(89.1±18.4)IU,B组(138.5±28.1)IU,C组(130.8±43.8)IU,A组与B组用量及A组与C组用量均有极显著差异(P<0.001),B组与C组用量差异无统计学意义(P=0.306);A组尿促性素总剂量(833.6±268.9)IU,B组(1 044.2±264.7)IU1,C组(1 344.5±867.9)IU,A组与B组总量无显著性差异(P=0.129),A组与C组总量有极显著性差异(P<0.001),B组与C组总量有显著性差异(P=0.024)。治疗时间A组和B组无显著差异(P=0.133),A组和C组有显著差异(P=0.018),B组和C组有显著差异(P=0.021)。各组间HCG日E2无显著差异(P>0.05);各组间子宫内膜厚度无显著差异(P>0.05);各组妊娠率无显著差异(P>0.05)。结论:PCOS患者的基础AMH可以作为促排卵治疗时预测促性腺激素剂量的重要指标;AMH高的患者只是治疗时间较长,妊娠率不受影响。Objective： To explore the effect of anti -mtillerian hormone （AMH） on exogenous gonadotropin dose during ovulation induction in patients with polycystic ovary syndrome （PCOS）, and evaluate the effect of AMH on outcome of ovulation induction. Methods： The levels of basic AMH and sex hormone in 123 patients with PCOS were detected, then the patients were divided into group A （42 pa- tients ）, group B （36 patients）, and group C （45 patients） according to AMH levels. Ovulation induction with gonadotropin was conducted, the doses of gonadotropin and outcomes in the three groups were compared. Results： The initial doses of urine gonadotropin in group A, group B, and group C were （ 89. 1 ~ 18.4） IU, （ 138. 5 ~ 28.1 ） IU, and （ 130. 8 ~ 43.8 ） IU, respectively, there was statistically signifi- cant difference between group A and group B, group C （P 〈 O. 001 ）, but there was no statistically significant difference between group B and group C （P = 0.306 ）; the total doses of gonadotropin in group A, group B, and group C were （833.6 ~ 268.9 ） IU, （ 1 044. 2 ~ 264. 7 ） IU, and （ 1 344. 5 ~ 867.9 ） IU, respectively, there was no statistically significant difference between group A and group B （ P = O. 129 ）, but there was statistically significant difference between group A and group C （ P 〈 0. 001 ）, as well as between group B and group C （P =0. 024） . There was no statistically significant difference in treatment time between group A and group B （P =0. 133）, but there was statistically significant difference between group A and group C （ P = O. 018 ） , as well as between group B and group C （ P = 0. 021 ） . There was no statistically significant difference in estradiol level on the day of human chorionic gonadotropin （HCG） injection （P 〉 0. 05 ）, thickness of endometrium, and pregnancy rate among the three groups （ P 〉 0. 05 ） . Conclusion： Basic AMH can be used as an important index to predict gonadotropin dose during ov

关 键 词：抗苗勒氏管激素 多囊卵巢综合征 尿促性素 

分 类 号：R711.75[医药卫生—妇产科学]