艾滋病患者抗病毒督导治疗疗效分析  

Analysis on effects of HAART from 377 Chinese AIDS

作　　者：李晓菲[1] 余祖江[2] 梁红霞[2] 何云[3] 江河清[2] 阚全程[1] 

机构地区：[1]郑州大学第一附属医院药剂科,郑州450052 [2]郑州大学第一附属医院感染科,郑州450052 [3]郑州市第六人民医院,郑州400050

出　　处：《郑州大学学报（医学版）》2013年第2期235-238,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：国家"十.五"攻关课题基金资助项目200413A719A13-05;200413A719A10;国家自然科学基金资助项目30472031

摘　　要：目的:探讨提高抗病毒疗效和服药依从性,延缓病毒耐药发生的方法。方法:377名来源于同一乡村的HIV感染者,分为督导治疗组(n=134)和未督导治疗组(n=243),均给予HAART治疗,仅督导治疗组患者给予严格督导治疗。分别于治疗后第1、2、3、6、9和12个月,抽取外周血,应用PCR检测HIV-RNA载量,流式细胞仪检测CD4+、CD8+T淋巴细胞数量,血常规检测白细胞数量变化。结果:随着治疗时间的延长,2组患者外周血CD4+、CD8+T淋巴细胞及白细胞数量均逐渐上升;2组间比较,差异无统计学意义。2组患者外周血HIV-RNA载量差异有统计学意义(F组间=3.781,F时间=2.561,F交互=352.79,P﹤0.05);治疗后6、9和12个月督导治疗组高于未督导治疗组。结论:督导治疗有利于持续抗病毒疗效,延缓耐药毒株的发生。Aim： To seek the suitable method for elevating the effects of HAART and delaying the emergence of the resistance. Methods： 377 AIDS patients from the same area were divided into the full supervision （ n = 134） and non-full supervision （ n = 134） treatment groups. All the patients were given the same HAART traerment for 12 months. At 1,2,3, 6,9,12 months after treatment,the HIV-RNA load were detected by PCR ,CD4 ＋ ,CD8 ＋ T cells were detected by flow cy- tometry ,and white blood cell （ WBC） were detected by routine blood test. Results： The counts of CD4 ＋ ,CD8 ＋ T cells elevated in the two groups ,and there were no obviously different. The HIV-RNA load between the two groups were different （ F group = 3. 781,F time = 2. 561,F interaction = 352. 791,P 0. 05） ; Non-full supervision treatment group was higher than the full supervision treatment group at 6,9,12 months after treatment. Conclusion： The full supervision treatment could delay the emergence of resistance and prolong the effect of HAART.

关 键 词：人类免疫缺陷病毒 高效逆转录病毒治疗 耐药 

分 类 号：R512.91[医药卫生—内科学]