血液灌流串联血浆置换治疗急性二氯丙醇中毒患者的效果  

Hemoperfusion combined with plasma exchange in the treatment of acute 1, 3-dichloropropanol poisoning

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作  者:胡蓬勃[1] 邱建清[1] 刘立云[1] 邢娜娜[1] 张卫延[1] 许玲[2] 

机构地区:[1]滨州医学院附属医院急诊科,256600 [2]滨州医学院附属医院呼吸重症医学科,256600

出  处:《国际移植与血液净化杂志》2013年第2期37-39,共3页International Journal of Transplantation and Hemopurification

摘  要:目的探讨血液灌流与血浆置换串联治疗急性二氯丙醇中毒的临床效果。方法对我院2010年1月至2012年12月收治的56例急性二氯丙醇中毒患者进行病例回顾研究。受试者分为两组,常规治疗组[n=26,其中男15例,女11例,年龄(33±15)岁]采用药物治疗,血液灌流串联血浆置换组[n=30,其中男19例,女11例,年龄(36±16)岁]采用药物治疗+血液灌流串联血浆置换治疗。观察两组患者多器官功能障碍综合征发生率、肝功能衰竭发生率、死亡率及平均存活时间。采用t检验和x2检验进行数据统计。结果血液灌流串联血浆置换组多器官功能障碍综合征发生率(43.33%vs80.77%)、肝功能衰竭发生率(53.33%vs92.31%)以及死亡率(26.67%vs69.23%)较常规治疗组低,平均存活时间延长[(13.8±3.7)vs(3.2±0.8)d],差异具有统计学意义(均P〈0.05)。结论血液灌流串联血浆置换治疗急性二氯丙醇中毒患者疗效显著。Objective To investigate hemoperfusion and plasma exchange in the treatment of acute 1,3-dichloropropanol poisoning. Methods Fifty-six patients who were treated for 1,3-dichlorepropanol poisoning during January 2010 and December 2012 were enrolled in this retrospective study. All the participants were assigned to the conventional treatment group ( n = 26, male 15, female 11, mean age (33 ± 15) years old) and the blood perfusion + plasma replacement group ( n = 50, male 19, female 11, mean age (36 ± 16) years old). Incidence of multiple organ dysfunction syndrome (MODS) and liver failure incidence, mortality and survival time were compared between the two groups. Student' s t test or x2 test was used for data analysis. Results The blood perfusion + plasma replacement group showed higher incidence of MODS (43.33% vs 80.77% ), higher incidence of hepatic failure (53.33% vs 92.31% ) and prolonged survival time ( ( 13.8 ± 3.7) vs (3.2 ± 0.8) d ) ( all P 〈 0.05). Conclusion Hemoperfusion with plasma exchange could effectively treat acute 1,3-dichloropropanol.

关 键 词:急性二氯丙醇中毒 血液灌流 血浆置换 

分 类 号:R5[医药卫生—内科学]

 

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