NADPH氧化酶调节慢性肾脏病时心脏成纤维细胞生长因子-2的表达  

NADPH Oxidase Regulates the Expression of Myocardial Fibroblast Growth Factor-2 in Chronic Kidney Disease

作　　者：刘宇[1] 黄辉[1] 陈洁[1] 张坤[1] 黄斐斐[1] 刘阳[1] 

机构地区：[1]中山大学孙逸仙纪念医院心血管内科,510120

出　　处：《岭南急诊医学杂志》2013年第1期4-5,9,共3页Lingnan Journal of Emergency Medicine

摘　　要：目的:在大鼠5/6肾切除模型上探讨心脏成纤维细胞生长因子-2(FGF-2)表达情况及NADPH氧化酶对FGF-2表达的影响。方法:构建5/6肾切除动物模型并给予NADPH氧化酶抑制剂apocynin干预8周,观察大鼠心肌组织FGF-2的表达情况。结果:apocynin改善5/6肾切除术导致的大鼠血压升高、体重下降及血肌酐的蓄积,并抑制5/6肾切除术导致心脏FGF-2表达。结论:NADPH氧化酶是调控慢性肾脏病(CKD)时心脏FGF-2的合成因素之一。Objective： To investigate the effects of NADPH oxidase on the expression of fibroblast growth factor- 2 （FGF-2） in chronic kidney disease （CKD）. Method： CKD models were established in male Sprague-Dawley rats and treated with apocynin for 8 weeks. Results： NADPH oxidase inhibition ameliorated 5/6 nephrectomy induced hypertension, weight loss and creatinine accumulation. Furthermore, apocynin treatment reduced the expression of cardiac FGF-2 in 5/6 nephrectomized rats. Conclusions： The study demonstrated that NADPH oxidase plays a pivotal role in regulating the expression of FGF-2 in CKD.

关 键 词：NADPH氧化酶 成纤维细胞生长因子-2 慢性肾脏病 

分 类 号：R692[医药卫生—泌尿科学]