高血压舒张性心力衰竭患者血清NT-proBNP、hs-CRP、TGF-β1的变化  

Changes of Serum NT-proBNP、hs-CRP、TGF-β1 in Patients with Hypertensive Diastolic Heart Failure

作　　者：王广兴[1] 翟原生[2] 孙华保[1] 李泽林[1] 

机构地区：[1]广东省湛江中心人民医院心内科,524037 [2]中山大学附属第一医院黄埔院区心血管内科

出　　处：《岭南急诊医学杂志》2013年第1期21-23,共3页Lingnan Journal of Emergency Medicine

摘　　要：目的:探讨高血压舒张性心力衰竭患者血清NT-proBNP、hs-CRP、TGF-β1水平与舒张功能的关系。方法:测定高血压舒张性心力衰竭患者(心衰组,n=82)及25例无器质性心脏病者(对照组,n=25)的血清NT-proBNP、hs-CRP和TGF-β1水平,同时采用彩色多普勒超声诊断仪测定左室射血分数(LVEF)、E/A及E/E'。结果:高血压舒张性心力衰竭患者的血清NT-proBNP和hs-CRP水平明显高于对照组(P<0.05),且与舒张功能呈负相关;高血压舒张性心力衰竭患者的血清TGF-β1水平明显低于健康人(P<0.05),且与舒张功能呈正相关。结论:在高血压舒张性心力衰竭患者中,hs-CRP、TGF-β1与心脏舒张功能状态密切相关,可能成为早期诊断舒张性心力衰竭及评估病情的重要指标。Objective： To explore the relationship between diastolic function and serum NT-proBNP,hs-CRP and TGF-β1.Method：Serum NT-proBNP,hs-CRP,TGF-β1 of patients with hypertensive diastolic heart failure （heart failure group ,n=82） and people without any cardiovascular disease （control group, n=25 ） were tested and LVEF, E/ A, E/E＇were detected by color Doppler ultrasonic instrument. Results： Compared with healthy people, serum NT- proBNP and hs-CRP were higher in heart failure group and negatively associated with diastolic function. Serum TGF- β1 were lower in heart failure group than that in control group and positively associated with diastolic function. Conclusion： In patients with hypertensive diastolic heart failure, serum NT-proBNP, hs-CRP,TGF-β1 were closely in relation with diastolic function and may be benefit for diagnosis of diastolic heart failure and assessment, of diastolic function.

关 键 词：舒张性心力衰竭 NT—proBNP hs—CRP TGF-Β1 

分 类 号：R541.6[医药卫生—心血管疾病]