早期目标导向治疗结合山莨菪碱对重度脓毒症患者预后的影响  

Effect on the Prognosis of Patients with Severe Sepsis Early Treated by Goaldirected Combined with Anisodamine

作　　者：邹毅成[1] 廖富毅[1] 李轶男[1] 周立新[1] 伍燕燕[1] 

机构地区：[1]广东省佛山市第一人民医院,528000

出　　处：《岭南急诊医学杂志》2013年第1期24-25,共2页Lingnan Journal of Emergency Medicine

基　　金：广东省佛山市卫生局医学科研课题(2011022)

摘　　要：目的:研究早期目标导向治疗(EGDT)和山莨菪碱对重度脓毒症患者预后的影响。方法:将2010年10月至2012年10月收住ICU的18岁以上重度脓毒症患者63例随机分配为治疗(EGDT和山莨菪碱)组和常规治疗对照组,比较两组24 h乳酸清除率,序贯器官衰竭估计(SOFA)评分的变化及血管活性药物使用时间、28 d机械通气时间、ICU停留时间和28 d病死率。结果:治疗组入选后24 h乳酸清除率明显高于对照组,3d和7d SOFA评分均明显低于对照组,治疗组血管活性药物使用时间、28 d内机械通气时间、ICU停留时间和28 d病死率均明显少于对照组,P均<0.05。结论:早期目标导向治疗和山莨菪碱可明显改善重度脓毒症患者的预后。Objective： To study the effect of early goal-directed therapy （EGDT） combined with Anisodamine on prognosis of patients with severe sepsis. Methods： 63 Patients with severe sepsis with 18 years older were randomly divided into treatment group and control group treated by early goal-directed therapy combined with Anisodamine and routine at the ICU from Oct 2010 to Oct 2012. The 24-hour lactate clearance, the SOFA score, the vasoactive agent application times, the mechanical ventilation times in 28 days, the length of ICU stay and the 28 days mortality were compared between the two groups. Results： Compared with the control group, 24-hour lactate clearance was significantly higher, the SOFA score at 3 days and 7 days were significantly lower, the vasoactive agent application times, the mechanical ventilation times in 28 days, the length of ICU stay and 28-day mortality rate were significantly lower, all P 〈 0.05. Conclusion： Application of EGDT combined with Anisodamine could improve the prognosis of patients with severe sepsis.

关 键 词：早期目标导向治疗 山莨菪碱 重度脓毒症 预后 

分 类 号：R459.7[医药卫生—急诊医学]