母血FE3、hPL检测胎盘功能对慢性胎儿宫内窘迫诊断价值的研究  

The study of measurement of maternal serum free estriol and human placetal lactonen levels detecting fetus-placenta function to diagnosis chronic fetal distress

作　　者：张淑莉 齐洪伟 

机构地区：[1]东莞市大朗医院,523770

出　　处：《中国实用医药》2013年第8期6-7,共2页China Practical Medicine

基　　金：东莞市科技术计划医疗卫生类科研一般项目(项目编号:201110515000135)

摘　　要：目的探讨使用孕妇血清游离雌三醇(FE3)和胎盘泌乳素(hPL)检测胎盘功能对慢性胎儿宫内窘迫的诊断价值。方法对612例晚期妊娠(≥32周)孕妇进行胎盘功能检查,用化学发光免疫分析方法测定血清FE3和hPL,其中1项或2项低于正常值者为胎盘功能低下。结果 612例晚期妊娠孕妇经过FE3和hPL检测确定胎盘功能低下组例数31例,无胎盘功能低下组581例;经过临床诊断为慢性胎儿窘迫者43例,无慢性胎儿窘迫569例;胎盘功能低下、慢性胎儿窘迫双阳性者25例。结论 FE3、hPL检测胎盘功能低下对慢性胎儿宫内窘迫有特异性高的诊断价值。Objective To evaluate the value of measurement of matemel serum free estriol （ FE3 ） and human placetal lactogen （hPL） levels detecting fetus-placenta function to diagnosis chronic fetal dis- tress. Methods Serum FE3 and hPL levels were measured with immunoassay（CLIA） in 612 late pregnant women for more than 32 weeks gestational age. The matemel serum FE3 or/and HPL levels which below normals was seemed as fetus-placenta function decline. Results The case number of fetus-placenta func- tion decline were 31 in 612 cases. The case number of chronic fetal distress were 43 in 612 cases. The case number of chronic fetal distress and fetus-placenta function decline were 25 in 612 cases. Conclusion There is high specificity in measurement of maternal sarum free estriol and human placetal lactogen levels detecting fetus- placenta function to diagnosis chronic fetal distress for late pregnant women.

关 键 词：游离雌三醇 胎盘泌乳素 化学发光免疫分析 胎盘功能 慢性胎儿窘迫 

分 类 号：R714.5[医药卫生—妇产科学]