布地奈德联合孟鲁司特治疗儿童感染后咳嗽的疗效观察  

Clinical study of budesonide combined with montelukast in the treatment of postinfectious cough

作　　者：林业辉[1] 范联[1] 周杏[1] 潘志伟[1] 陈进喜[1] 陈昭仪[1] 陈亮[1] 

机构地区：[1]南方医科大学附属佛山市妇幼保健院儿科,广东佛山528000

出　　处：《临床医学》2013年第3期8-10,共3页Clinical Medicine

基　　金：广东省佛山市卫生局立项课题(2011176)

摘　　要：目的探讨布地奈德联合孟鲁司特治疗儿童感染后咳嗽的临床疗效。方法按感染后咳嗽诊断标准入选病例150例,随机分成三组。对照组给予酮替芬和复方甘草合剂治疗,布地奈德治疗组在对照组基础上加用布地奈德雾化吸入,联合治疗组在布地奈德治疗组基础上加用孟鲁司特口服,分别于第3、7天对三组进行疗效评价。结果第3天时联合治疗组和布地奈德治疗组咳嗽评分比较差异无统计学意义(P>0.05);但均低于对照组(P<0.05)。第7天时联合治疗组咳嗽评分低于布地奈德治疗组和对照组(P<0.05)。联合治疗组治疗7 d后总有疗效率为88%,高于布地奈德治疗组的74%和对照组的52%(P<0.05)。结论布地奈德与孟鲁司特联合治疗能有效控制感染后咳嗽患儿的临床症状。Objective To investigate the clinical efficacy of budesonide combined with montelukast in the treatment of children with postinfectious cough.Methods One hundred and fifty cases were selected according to the diagnostic criteria of postinfectious cough,and they were randomly divided into three groups.Children in control group were treated with ketotifen and mixture brown,budesonide treatment group were given budesonide inhalation based on the treatment of the control group,children in combined treatment group were given oral montelukast based on the treatment of the Budesonide treatment group.The efficacy of the three groups was evaluated at the 3rd and 7th day.Results There was no statistically significant differences of the cough score between combined treatment group and budesonide treatment group at the 3rd day（P0.05）,but it was lower than that of the control group（P0.05）.The cough score of the combination theatment group was lower than that of the budesonide treatment group at the 7th day,and lower than that of the control group（P0.05）.The total efficacy rate of the combination therapy group was 88% at the 7th day,it was higher than that of the Budesonide treatment group（74%） and the control group（52%）,P0.05.Conclusion Budesonide and montelukast combination therapy can be effective to control the clinical symptoms of postinfectious cough in children.

关 键 词：感染后咳嗽 儿童 气道高反应性 布地奈德 孟鲁司特 

分 类 号：R725.6[医药卫生—儿科]