上海市部分绝经后女性维生素D水平与认知障碍的相关性  

Association between 25-hydroxyvitamin D levels and cognitive impairment in postmenopausal women in Shanghai

作　　者：陈琳[1] 游利[1] 陈瑾瑜[1] 潘凌[1] 彭永德[1] 

机构地区：[1]上海交通大学附属第一人民医院内分泌代谢科,上海200080

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2013年第1期15-19,共5页Chinese Journal Of Osteoporosis And Bone Mineral Research

摘　　要：目的探讨上海市部分绝经后妇女维生素D水平与认知障碍之间的相关性。方法选取2011年9月至11月在上海市第一人民医院骨质疏松门诊初次就诊的绝经后女性111例,根据血清25羟维生素D(25OHD)水平分为维生素D正常组(25OHD≥50mmol/L)和维生素D缺乏或不足组(25OHD<50mmol/L)。对所有入选者进行认知障碍评估,包括简易智能状态量表(MMSE)和蒙特利尔认知评估(MoCA)。采用电化学发光法测定血清25OHD水平,采用美国GE公司双能X线骨密度吸收仪测定正位腰椎1-4和左全髋骨密度(BMD)。结果维生素D缺乏组血清25OHD水平显著低于维生素D正常组,差异有统计学意义(P<0.001);2组患者MMSE评分及MoCA评分比较差异无统计学意义(P>0.05);多元Logistic回归分析结果提示,维生素D水平与MMSE评分及MoCA评分均无相关性(OR=1.552,P=0.489;OR=1.169,P=0.448),校正年龄、文化程度、绝经年龄、绝经年限后,相关性仍无显著性差异(OR=1.408,P=0.662;OR=1.259,P=0.602)。结论上海市部分绝经后女性血清维生素D水平与认知功能间无相关性,宜进一步扩大样本量或行前瞻性研究以确定其是否相关。Objective To investigate the association between low serum 25-hydroxyvitamin D [ 25OHD ] con- centration and cognitive impairment in postmenopausal women in Shanghai. Methods 111 postmenopansal women were divided into 2 groups according to serum 25OHD concentrations （deficient group： 25OHD 〈 50 nmol/L, normal group： 25OHD≥50 nmol/L）. Cognitive function was assessed using the Mini-Mental State Examination （MMSE） and Montreal Cognitive Assessment （MoCA）. Serum 25OHD levels were measured by electrochemiluminescence assays Bone mineral density （BMD） at lumbar spine 1-4 （ Ll.4 ） and femoral neck （Neck） were measured by duel-energy X-ray absorptiometry （DXA）. Results The serum 25OHD concentration of normal group was significantly higher than deficient group （P 〈 0. 001 ）. There was no significant difference of MMSE or MoCA between normal group and deficient group （P 〉 0. 05 ）. In an unadjusted logistic regression model, there was no significant association between serum 25OHD concentration and MMSE score or MoCA score （ odds ratio [ OR] = 1. 552, P = 0. 489 ; OR = 1. 169, P = 0. 448）. In a model adjusted for age, education, menopause age and menopause year, the association was still no significant （ OR = 1. 408, P = 0. 662 ; OR = 1. 259, P = 0. 602）. After adjusting for additional confounders, 25OHD levels were not associated with MMSE score or MoCA （OR=1.247, P=0.805; OR=1.235, P=0.670）. Conelusio, 25OHD concentrations are not associatedwith cognitive impairment in postmenopausal women in Shanghai.

关 键 词：维生素D 认知障碍 简易智能状态量表 蒙特利尔认知评估 

分 类 号：R681[医药卫生—骨科学]