丹皮酚胃黏附片的制备及体外释放的研究  

Preparation and in vitro release study of paeonol gastric adhesive tablets

作　　者：高敬轩[1] 夏玫[1] 张娇[1] 李佳[1] 贺英菊[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2013年第2期132-135,共4页West China Journal of Pharmaceutical Sciences

摘　　要：目的制备丹皮酚胃黏附片并评价其体外释药机制。方法以累积释放度和体外黏附力为指标,通过单因素试验筛选黏附片各辅料种类及用量,用均匀设计实验优化处方。结果最优处方下制备的丹皮酚胃黏附片在10 h累积释放度可以达到85%以上,黏附力为62.35 g.cm-2体外释放符合Peppas方程。结论丹皮酚胃内黏附片的处方基本满足设计要求。OBJECTIVE To prepare the paeonol gastric adhesive tablet and evaluate its release characteristics in vitro. METHODS With in vitro cumulative release and adhesion as indicators, single - factor tests are made to screen the type and the amount of excipients of paeonol gastric adhesive tablets and a uniform experiment design is applied to optimize the prescription. RESULTS The cumulative release of paeonol gastric adhesive tablets prepared under the optimal prescription could reach more than 85% at 10 h. Its adhesion was 62.35 g· cm -2 and its release profiles in vitro fitted well with the Peppas equation. CONCLUSION The prescription of paeonol gastric adhesive tablets basically met the design of requirements.

关 键 词：丹皮酚 均匀设计 黏附力 

分 类 号：R94[医药卫生—药剂学]