含二茂铁基的1,3,4-噻二唑化合物的合成及其生物活性研究  

Synthesis and biological activity of 1,3,4-thiadiazole compounds containing ferrocenyl moiety

作　　者：苟小锋[1] 李媛[1] 陈邦[1] 高学祥[1] 

机构地区：[1]西北大学化学与材料科学学院合成与天然功能分子化学教育部重点实验室,陕西西安710069

出　　处：《化学试剂》2013年第4期305-308,共4页Chemical Reagents

摘　　要：甲酰二茂铁与2-氨基-5-烷基/芳基-1,3,4-噻二唑在硅胶催化下反应,经硼氢化钾还原后得到18种新型2-二茂铁甲胺基-5-烷基/芳基-1,3,4-噻二唑。并通过IR、1HNMR和ESI/MS对其结构进行了表征。初步生物活性测试结果表明,部分化合物具有良好的生长调节活性。A series of novel N-（ferrocenyl-methyl）-5-alkyl/aryl-1,3,4-thiadiazol-2-amines were synthesized by the condensation of ferrocenecarboxaldehyde with 2-amino-5-alkyl/aryl-1,3,4-thiadiazoles in presence of silica gel and then reduction by potassium borohydride.All products were characterized by IR,1HNMR,and ESI/MS.Further,all synthesized compounds were screened for their auxin activity.Most of the compounds showed potent activity.

关 键 词：1 3 4-噻二唑 二茂铁 席夫碱 生物活性 

分 类 号：O627.8[理学—有机化学]