饮茶与中老年人骨质疏松性髋骨骨折关系的病例对照研究  

A case-control study regarding tea consumption and risk of hip fractures in middle-aged and elderly Chinese

作　　者：谢海丽[1] 欧阳维富[2] 吴宝华 涂素兰[4] 薛文琼[2] 樊帆[2] 陈裕明[2] 

机构地区：[1]中山大学公共卫生学院医学统计与流行病学系,广州510080 [2]广东省人民医院 [3]广州市越秀区正骨医院 [4]江门市白石正骨医院

出　　处：《中华流行病学杂志》2013年第4期385-388,共4页Chinese Journal of Epidemiology

基　　金：国家自然科学基金（30872100,81072299）

摘　　要：目的探讨饮茶与骨质疏松性髋骨骨折的关系。方法采用1：1配对病例对照方法，于2008年1月至2012年6月通过面对面访问，对广东省4家医院581例55—80岁中老年骨质疏松性髋骨骨折新发病例及性别、年龄（±3岁）配对的581名对照进行问卷调查。调查内容包括一般情况、详细的饮茶及其他饮食情况、健康相关行为和骨折家族史等。结果单因素条件logistic分析显示，饮茶显著降低髋骨骨折风险。饮茶年限越长，每周饮茶次数越多，每年饮茶量越多，饮茶总量越多，或饮茶越浓，骨折发生的危险就越低（趋势检验P〈0．05）。与不饮茶者相比，饮茶及不同时间、频率、剂量及不同茶叶类型者的OR值为0．54～0．74（P〈0．05）。在校正年龄、能量、BMI、文化程度、父母骨折病史、“二手烟”暴露史、是否服用钙补充剂及体力活动能量消耗当量等因素后，上述关联仍具显著的线性趋势，但关联的强度略微降低。分层分析显示饮茶的效应仅在男性中有统计学意义，在不同文化程度人群亚组中的差异无统计学意义。结论规律性饮茶可降低中老年男性骨质疏松性髋骨骨折的风险。Objective To assess the impact of tea consumption on the risk ofosteoporotic hip fractures. Methods Between January 2008 and June 2012, 581 （148 males, 433 females） incident cases of hip fractures were enrolled from four hospitals in Guangdong province, with 581 sex- and age-matched （ ± 3 years） controls from either hospitals or communities. Face-to-face interviews were conducted to collect data pertaining to tea drinking and various covariates. Results Results from univariate conditional logistic analyses showed that an inverse association was observed in tea drinking and hip fracture risk. Longer time, greater frequency and dosage of tea consumption were dose-dependently associated with lower risk of hip fractures （P-trend 〈0.05）. Compared to non-drinkers, the odd ratios related to regular tea drinkers, subgroups with different length, frequency, dosage, type of tea consumption were ranged between 0.54 and 0.74 （all P〈0.05）. After adjustment for factors as age, daily energy intake, BMI, education levels, passive smoking, calcium supplement and physical activity, the dose-dependent associations among above said factors still remained significant. However, the strength of the association lowered slightly. The beneficial effect of tea was significant only in men but not in women. Similar effects were found in subjects with different education levels. Conclusion Regular tea drinking habit might decrease the risk of osteoporotic hip fractures in the elderly males.

关 键 词：髋骨骨折 茶 病例对照研究 

分 类 号：R6[医药卫生—外科学] R5[医药卫生—临床医学]