雷公藤多苷对糖尿病大鼠肾脏病变的疗效观察  

Curative Effects of Tripterygium Glycosides on Renal Changes in Diabetic Nephropathy Rats

作　　者：常景芝[1] 王琛[1] 陈剑[1] 

机构地区：[1]商丘医学高等专科学校基础医学部,河南商丘476100

出　　处：《中华中医药学刊》2013年第4期839-840,共2页Chinese Archives of Traditional Chinese Medicine

基　　金：河南省教育厅自然科学研究计划项目(2011C310003)

摘　　要：目的:研究雷公藤多苷(TG)对糖尿病(DM)大鼠肾脏病变的治疗效果。方法:将45只健康雄性大鼠SD大鼠随机分为正常对照组、模型组和雷公藤多苷治疗组,模型组、雷公藤多苷治疗组用链尿佐菌素(STZ)腹腔注射法构建糖尿病大鼠模型,用雷公藤多苷对糖尿病大鼠模型进行治疗观察。结果:雷公藤多苷对降低链尿佐菌素大鼠肾病的血糖、尿素氮、血肌酐均有显著作用。结论:雷公藤多苷对链尿佐菌素大鼠肾病有显著的疗效,能明显改善肾脏功能。Objective ： To investigate the treatment effects of TG on renal changes in DN rats. Methods ： Forty - five male SD rats were randomly divided into normal control group, diabetic nephropathy（DN） group and diabetic nephropathy group treated with Tripterygium Glycosides（TG group）. DN group and TG group rats were intraperitoneal injected with strepto- zotocin （STZ）. Results：Tripterygium Glycosides played a significant role on declined blood glucose, Bun and Cr. Conclu- sions：TG has significant curative effect on STZ rats,greatly improving the renal function.

关 键 词：雷公藤多苷 糖尿病肾病 血肌酐 尿白蛋白 

分 类 号：R285.5[医药卫生—中药学]