血清急性时相蛋白检测在消化系统恶性疾病诊断中的意义  

Application of serum acute phase proteins detection in diagnosing of malignant digestive system disease

作　　者：张绍平[1] 

机构地区：[1]重庆市綦江区人民医院肠胃外科,重庆綦江401420

出　　处：《海南医学院学报》2013年第4期490-491,495,共3页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金项目(112210593)~~

摘　　要：目的:探讨急性时相蛋白检测在消化系统恶性疾病诊断的临床意义。方法:选取我院150例胃癌,结、直肠癌患者在术前行血清α1-酸性糖蛋白(α1-AG)、α1-抗胰蛋白酶(α1-AT)、C-反应蛋白(CRP)浓度检测,并与同期收治的消化系统良性疾病、应激患者及健康体检者进行对比观察。结果:消化系统良性疾病患者血清α1-AG、α1-AT、CRP水平比健康对照组略有增高,但差异无统计学意义(P>0.05);消化系统恶性疾病患者术前血清α1-AG、α1-AT、CRP水平较良性疾病组与健康对照组显著增高,差异有统计学意义(P<0.05)。结论:急性时相蛋白在消化系统恶性疾病中增高显著,表明急性时相蛋白的检测对胃肠良、恶性肿瘤的辅助诊断具有重要的临床意义。Objective- To discuss the application of serum acute phase proteins detection in diagno- sing malignant digestive system disease. Methods： A total of 150 cases with gastric cancer and colorectal cancer from our hospital were enrolled and al-AG, al-AT and CRP concentration were detected before surgery. Patients with benign digestive system disease, stress response and healthy participants from the same period were observed for comparison. Results： Patients with benign digestive system disease had slightly higher levels of al-AG, a-AT and CPR than healthy controls. However, the difference was not statistically significant （P〈0.05）. α1-AG,al-AT and PCR levels in patients with malignant digestive sys- tem disease before surgery were significantly higher than that in benign disease group and healthy control group （P〈0.05）. Conclusions. Acute phase proteins increase significantly in malignant digestive system disease, indicating that acute phase protein detection has great clinical significance in the assist diagnosis of malignant and benign gastroenteric cancers.

关 键 词：胃肠道肿瘤 胃癌 大肠癌 急性时相蛋白 

分 类 号：R453[医药卫生—治疗学]