针刺足三里对FD胃排空及血清Motilin和Ghrelin的影响  

Changes of Gastric Emptying and Serum Motilin and Ghrelin by Needling Zusanli of Functional Dyspepsia

作　　者：羊燕群[1] 候陈凤[2] 彭丹[2] 潘锋[1] 马志杭[1] 陈建永[1] 

机构地区：[1]杭州市红十字会医院消化科,浙江杭州310003 [2]浙江中医药大学,浙江杭州310053

出　　处：《中华中医药学刊》2013年第4期881-883,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：杭州市科技局重点专科专病资助项目(20100733Q22)

摘　　要：目的:观察针刺穴位足三里对功能性消化不良(Functional Dyspepsia,FD)促进胃排空的治疗作用及对照研究血清Motilin和Ghrelin的变化。方法:采用适度夹尾刺激法复制FD大鼠模型,分别予电针刺激足三里穴位及对照性西药治疗,测定各组大鼠摄食量、体重、胃残留率、碳末推进率及血清Motilin和Ghrelin浓度。结果:模型组、西药组和针刺组摄食量与空白组比较均显著下降;西药组与针刺组胃残留率减少;西药组和针刺组相应的碳末推进率较空白组显著升高;模型组大鼠血清Motilin浓度显著下降;模型组大鼠血清Ghrelin相对升高,但无统计学意义。结论:中医手法针刺足三里对胃肠动力有促进作用,可能与恢复功能性消化不良大鼠的Moti-lin、Ghrelin水平有相关性。Objective： To observe the treatment of needling Zusanli of functional dyspepsia rats on gastric emptying, and to study the changes of serum concentration of motilin and ghrelin. Method ： The rats were randomly divided into nor- mal group（NG）, model group（MG）, Western Medicine group（WG） and Acupuncture group（AG）. The differences of food intake, weight, gastric residual rate, and carbon propulsion rate of all the rats, as well as the serum concentration of motilin and ghrelin were compared. Results： Food intake of MG, CG and WG was much lower than that of the normal group, but that of AG was higher than that of MG. Gastric residual rate of WG and AG was lower than that of NG, and the corresponding carbon propulsion rate was higher than that of NG. The motilin of MG was much lower than that of NG. The ghrelin of WG was lower than that of the MG. Conclusion ： Needling Zusanli has the therapeutic effect of promoting gastric emptying of functional dyspepsia. The effect may be related with recovering the serum concentration of motilin and ghrelin levels.

关 键 词：功能性消化不良 针刺 胃排空 MOTILIN GHRELIN 

分 类 号：R245.97[医药卫生—针灸推拿学]