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作 者:陈辉[1] 陈纪藩[2] 陈光星[2] 林昌松[2] 卢卫国[2] 刘清平[2]
机构地区:[1]广东医学院附属南山医院,广东深圳518052 [2]广州中医药大学第一附属医院,广东广州510405
出 处:《中华中医药学刊》2013年第4期919-921,I0011,共4页Chinese Archives of Traditional Chinese Medicine
摘 要:目的:观察川续断对昆明山海棠致大鼠睾丸毒性损伤作用的影响。方法:54只成熟雄性SD大鼠,随机分成3组,每组18只:空白对照组喂服生理盐水10 mL.kg-1.d-1,中药组喂服川续断水煎剂2.5 g.kg-1.d-1加昆明山海棠水煎剂7.5 g.kg-1.d-1,模型组喂服昆明山海棠水煎剂7.5 g.kg-1.d-1。连续60 d后,随机处死半数大鼠,取材。余下大鼠恢复饲养72 d后,处死取材。检测睾丸系数、睾丸体积、精子密度、形态、活力等。光镜观察睾丸组织的病理变化。结果:给药60 d,与模型组比较,中药组睾丸系数、精子密度均有显著提高(P<0.01)。停药72 d后,中药组精子活动力恢复,运动活跃,光镜下睾丸组织几乎无病理损伤;模型组精子形态异常、活力丧失,光镜下睾丸组织损伤,未见恢复迹象。结论:一定条件下,川续断能够拮抗昆明山海棠对雄性大鼠的生殖损伤作用。Objective : To observe the effects of Himalayan Teasel Root (HTR) on infertility induced by Tripterygium Hypoglaucum Hutch(THH)in rats. Methods:54 SD male rats were randomly divided into 3 groups, 18 in each group. The control group were given normal saline at a dose of 10 mL · kg^-1· d-1. The treatment group were given THH at a dose of 2.5 g · kg^- 1 · d^- 1 and Himalayan Teasel Root (HTR)at a dose of 7.5 g · kg^- 1 · d^- 1, and the model group were given THH at a dose of 7.5 g · kg^- 1 · d^- 1. After 60 days, half rats of each group were sacrificed randomly. The rest rats were continually raised until 72 days later, then sacrificed. The relative testis weight, testicle volume, sperm density and the total activity were comparatively analyzed. The pathological changes in testicular tissue were observed by optical mi- croscope. Results : Compared with the model group,it was significantly higher of relative testis weight and sperm density in the treatment group after a 60 -day treatment( P 〈 0.01 ). 72 days later ,in treatment group sperm motility recovered and there was no testicular lesion in rats. In model group the motility of sperm from caudal epididymides dropped to zero, and diastrophie sperms were seen. The tcsticular lesion in rats caused by THH was serious. It was not found that epididymal lesion recovered after 72 days. Conclusion:It indicated that in male rats, HTR eould relieve the reproductive lesions in- dueed by THH.
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