产生抗肿瘤抗生素Sandramycin的南极放线菌C_(3905)  

A ACTINOMYCETE STRAIN C_(3905) PRODUCING ANTITUMOR ANTIBIOTIC SANDRAMYCIN FROM ANTARCTICA

作　　者：胡继兰[1] 张春颖[1] 娜仁 李毅[1] 

机构地区：[1]中国医学科学院中国协和医科大学医药生物技术研究所,北京100050

出　　处：《微生物学报》2000年第6期646-651,共6页Acta Microbiologica Sinica

基　　金：国家自然科学基金资助!( 3 92 70 0 1 2 )&&

摘　　要：从南极乔治王岛土壤分离到一株诺卡氏菌形放线菌C390 5菌株。其气生菌丝白色 ,基内菌丝无色至乳脂或浅粉 ;菌丝直径 0 5～ 0 8μm ,断裂为杆状和球状体 ,表面光滑。胞壁化学I型 ;无枝菌酸 ;磷酸类酯PI型 ;优势甲基萘酯为MK 9(H4)。DNA中G +C含量为 68 3～ 68 9mol%。兼性嗜冷 ,生长适温为 1 5℃～ 2 0℃。产生抗肿瘤抗生素sandramycin。基于以上特征及分子遗传分类的研究结果 ,我们建议C390 5菌株作为白色类诺卡氏菌的一个变种 ,命名为白色类诺卡氏菌南极变种 ,Nocardioidesalbusvar.antarcticus。A nocardioform actinomycete strain C 3905 was isolated from a soil sample collected in King Geoge island,Antarctica.Its aerial mycelium is white,substrate mycelium is colorless to cream or pink.The hyphae of mycelium 0.5μm～0.8μm in diameter and they fragment into irregular rod to coccoid elements with smooth surface.Cell wall type I. The mycolic acids are lacking.Mk 9(H 4) is the predominant menaquinone component.Phospholipid type PI.The G+C content of DNA is 68.3～68.9mol%.Facultative psychrophile.The optimum temprature for grouth is 15℃～20℃.Produces antitumor antibiotic sandramycin.Based on the characteristics above as well as the investigation of the molecular genetics.We propose that strain C 3905 should be placed in the Nocardioides albus as a variant,named Nocardioides albus var. antarcticus.

关 键 词：白色害诺卡氏菌南极变种 抗瘤 放线菌 抗生素 

分 类 号：Q939.92[生物学—微生物学]