宫内环境与儿童代谢综合征的相关性研究  

Correlation study of children metabolism syndrome with intrauterine environment

作　　者：郑敏亚 

机构地区：[1]浙江省温岭市妇幼保健院妇产科,浙江温岭317500

出　　处：《中国医药导报》2013年第12期71-73,共3页China Medical Herald

基　　金：浙江省温岭市科技计划项目(编号2012C31115)

摘　　要：目的探讨母体因素及宫内环境与儿童代谢综合征(MS)的相关性。方法选择2009年1月～2010年12月温岭市妇幼保健院产检并住院顺利分娩且胎儿存活的孕妇3204例,对孕妇的一般情况、糖代谢指标、脂代谢指标以及不良妊娠结局、分娩方式及结局进行检测,同时对婴幼儿喂养方式及发育情况进行随访,采用Logistic回归分析母体因素及孕期宫内环境与儿童代谢综合征的相关性。结果 3204例儿童中共检出MS患儿226例,儿童MS发病率为7.05%。单因素Logistic回归分析结果显示,孕妇年龄、体重指数(BMI)、胰岛素抵抗指数(RI)、妊娠糖尿病(GDM)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,妊娠高血压综合征(PIH)、宫内发育迟缓及宫内窘迫、分娩方式、新生儿体重及喂养方式是儿童MS的相关因素(均P<0.05);多因素Logistic回归分析结果显示,BMI、TC和RI增高、合并GDM、PIH、宫内发育迟缓是儿童MS的危险因素(均P<0.05),新生儿体重正常及母乳喂养是儿童MS的保护性因素。结论孕期宫内环境、母体因素及喂养方式对儿童MS发生具有明显的影响,具有MS高危因素的婴幼儿在发育过程中要进行重点监测及干预。Objective To investigate the correlation of children metabolism syndrome （MS） with intrauterine environment and mother factor. Methods 3204 cases of gravida who received antenatal examination and delivery in Maternal and Child Health Center of Wenling City were selected; general state of health, glycometaholism index, lipid metabolism index, adverse pregnancy outcomes, delivery way and outcome were detected, feeding patterns and growth conditions of young children were followed up. Correlation of children MS with intrauterine environment and mother factor was analyzed by Logistic regression analysis. Results 226 cases were found with MS in 3204 children, incidence rate of child MS was 7.05%. Gravida age, body mass index （BMI）, insulin resistance index （RI）, gestational diabetes mellitus （GDM）, total cholesterol （TC）, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C）, pregnancy-induced hypertension syndrome （PIH）, intrauterine growth retardation, intrauterine distress, delivery way, newborn body weight and feeding way were the correlation factors of children MS according to the one factor Logistic regression analysis （P 〈 0.05）; higher level of BMI, TC and RI, complicating GDM and PIH, intrauterine growth retardation were the risk factors of children MS according to the multiple factor Logistic regression analysis （P 〈 0.05）, normal newborn body weight and breast feeding were protection factors of child MS. Conclusion Intrauterine environment, mother factor and feeding way have notable effect for child MS invasion, it is right to take intensive mon itoring and intervention in children with high risk factors of MS.

关 键 词：儿童代谢综合征 宫内环境 妊娠 糖代谢 脂代谢 

分 类 号：R714.51[医药卫生—妇产科学]