尿微量清蛋白、血清胱抑素、尿视黄醇结合蛋白在糖尿病肾病不同分期检测中的临床价值  

Clinical value of urinary microalbumin, serum cystatin, urinary retinol binding protein in detection of diabetic nephropathy in different stages

作　　者：张日赤[1] 杨赫[1] 

机构地区：[1]黑龙江省医院,黑龙江哈尔滨150000

出　　处：《中国当代医药》2013年第12期41-42,共2页China Modern Medicine

摘　　要：目的探讨尿微量清蛋白、血清胱抑素、尿视黄醇结合蛋白在糖尿病肾病不同分期检测中的临床价值。方法选取本院2011年1月～2012年8月糖尿病肾病患者58例为观察组,根据病症程度分为观察Ⅰ组(轻)、观察Ⅱ组(中)、观察Ⅲ组(重),选取同期健康体检人员30例为对照组,分析各组对象的尿微量清蛋白、血清胱抑素、尿视黄醇结合蛋白水平。结果观察Ⅰ组尿微量清蛋白高于对照组,差异无统计学意义(P>0.05)。观察Ⅰ组血清胱抑素、尿视黄醇结合蛋白水平均显著高于对照组,观察Ⅱ组尿微量清蛋白、血清胱抑素、尿视黄醇结合蛋白水平均显著高于对照组、观察Ⅰ组,观察Ⅲ组尿微量清蛋白、血清胱抑素、尿视黄醇结合蛋白水平均显著高于对照组、观察Ⅰ组、观察Ⅱ组,差异均有统计学意义(P<0.05)。结论尿微量清蛋白、血清胱抑素、尿视黄醇结合蛋白在糖尿病肾病不同分期检测中具有重要的临床价值,可作为判断病症程度的诊断指标。Objective To investigate clinical value of urinary microalbumin, serum cystatin, urinary retinol binding protein in detection of diabetic nephropathy in different stages. Methods Fifty-eight patients with diabetic nephropa- thy were selected in hospital from January 2011 to August 2012 as observation group. According to disease degree, pa- tients were divided into observation I group （light）, observation H group （middle）, observationlll group （heavy）. 30 health physical examination personnels were selected at same period as control group. Urinary microalbumin, serum cystatin, urinary retinol binding protein were detected. Results Urinary microalbumin, in observation I group was higher than control group, while the differenee was not statistic^ly significant （P 〉 0.05 ）. Serum cystatin, urinary retinol binding protein in observation I group were significantly higher than control group. Urinary microalbumin, serum eystatin, uri- nary retinol binding protein in observation II group were significantly higher than control group, observation I group. Urinary mieroalbumin, serum cystatin, urinary retinol binding protein in observation HI group were significantly higher than control group, observation I group, observation II group, the differences were statistically significant （P 〈 0,05 ）. Conclusion Urinary microalbumin, serum cystatin, urinary retinol binding protein have important clinical value in de- tection of diabetic nephropathy in different stages, which can be used as diagnostic indicators of disease severity.

关 键 词：尿微量清蛋白 血清胱抑素 尿视黄醇结合蛋白 糖尿病肾病 临床价值 

分 类 号：R587.1[医药卫生—内分泌]