阿托伐他汀对不稳定型心绞痛患者血脂及hs-CRP、TNF-α水平的影响  

Effect of atorvastatin on the levels of blood lipids and hypersensitive C-reaction protein and Tumor necrosis factor-α for unstable andina pectoris

作　　者：黄梦照[1] 梁东[1] 蒙应写[1] 廖驰林[1] 刘华勇[1] 胡强[1] 

机构地区：[1]广西壮族自治区百色市人民医院心内科,广西百色533000

出　　处：《中国当代医药》2013年第12期88-89,共2页China Modern Medicine

摘　　要：目的探讨阿托伐他汀对不稳定型心绞痛(UAP)患者血脂及hs-CRP、TNF-α水平的影响。方法将96例UAP患者随机分为两组,对照组仅给予常规抗心绞痛治疗,观察组在对照组基础上加用阿托伐他汀。结果治疗后两组患者hs-CRP和TNF-α水平均比治疗前明显下降(P<0.05),观察组下降更为显著(P<0.05);观察组TC、TG、LDL-C水平均比治疗前明显下降(P<0.05),HDL-C水平则明显上升(P<0.05)。结论阿托伐他汀治疗UAP可明显降低血脂及减轻炎症反应,有助于进一步改善患者预后。Objective To explore the effect of atorvastatin on the levels of blood lipids and hypersensitive C-reaction protein （hs-CRP） and Tumor necrosis factor-α （TNF-α） for unstable andina pectoris. Methods The 96 patients with UAP were divided randomly into two groups. The control group were given antianginal therapy, and the observation group were treated as the same with control group plus atovastatin. Results After treatment~ there was significant im- provement in the level of hs-CRP and TNF-α（P 〈 0.05）, in the observation group the changes were more obvious than that of the control group （P 〈 0.05）. The levels of TC, TG, LDL-C in observation group decreased significantly than that before treatment （P 〈 0.05）, the level of HDL-C was significantly higher than before treatment （P 〈 0.05）. Conclusion Atovastatin can reduce the levels blood lipids and extenuate the inflammatory response, help to further improve the prognosis.

关 键 词：阿托伐他汀 不稳定型心绞痛 血脂 超敏C反应蛋白 肿瘤坏死因子-α 

分 类 号：R972[医药卫生—药品]