表雄酮的合成  

The Synthesis of 3β-Acetoxy-5a-androstan-17-one

作　　者：张志花[1] 倪珊梅[1] 顾庆美[1] 

机构地区：[1]华南农业大学理学院,广东广州510642

出　　处：《广东化工》2013年第8期25-26,共2页Guangdong Chemical Industry

摘　　要：表雄酮是激素类药物中的重要中间体。本研究以华南地区丰富的剑麻皂素为起始原料,经乙酰基保护、开环、氧化、水解、消除得到单烯醇酮醋酸酯,然后经肟化、Bechmann重排和水解得到表雄甾酮,整个研究采用类似一锅法得到目标产物,收率高。3β-Acetoxy-5a-androstan-17-one is an important intermediate in the hormone drugs. This paper was to use the tigogenin as the raw material to gain single enol ketone acetate by acetyl protection, ring-opening, oxidation, hydrolysis and elimination reaction, and then to further get 3β-Acetoxy-5a-androstan- 17-one through oximation, Bechmann rearrangement and hydrolysis. The whole research utilized the similar one-pot reaction method to obtain our final preparation with a high yield.

关 键 词：剑麻皂素 类似一锅法 单烯醇酮醋酸酯 表雄酮 

分 类 号：O629.23[理学—有机化学]