正常健康者不确定奖赏抉择加工过程激活脑区分析  

Analysis of activated brain areas in uncertain rewarding processing of decision making on healthy volunteers

作　　者：陈娟[1] 郭宗君[1] 刘世恩[2] 李玉焕[3] 孙波[3] 高振波[3] 

机构地区：[1]青岛大学医学院附属医院特需保健科,青岛大学脑科学与人力资源管理研究所,青岛266003 [2]青岛大学医学院附属医院影像医学科,青岛266003 [3]青岛市精神卫生中心

出　　处：《中华行为医学与脑科学杂志》2013年第3期240-242,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：山东省科技发展计划项曰（2011YDl8045）;山东省自然科学基金项目（ZR2012HM049）;山东省保基金资助项目（2007BZ19）;青岛市科技局基金资助项目（Kzd-03;09-1-1-33-nsh）

摘　　要：目的分析正常健康者不确定奖赏抉择加工过程的激活脑区情况。方法15名正常健康者进行3种不同程度（确定、风险、含糊）奖赏抉择实验，通过GE3．0T磁共振与脑功能视听觉刺激系统时受试者进行大脑同步扫描。采用SPM8分析获得相关激活脑区和激活强度值。结果确定奖赏抉择时眶额叶被激活，平均激活强度2．4328±0．1949（P〈0．05）；风险奖赏抉择时前额叶、中央前回、枕叶联合视皮层、顶下小叶、小脑后叶、颞中回、颞下回、边缘叶及中脑被激活，平均激活强度2．4228±1．3762（P〈0．05）；含糊奖赏抉择时前额叶、颞极区及颞下回、枕叶视皮层、小脑后叶被激活，平均激活强度2．4056±0．4222（P〈0．05）。风险奖赏抉择与确定奖赏抉择比较，腹外侧前额叶、前额叶额极、眶额叶、中央前回、颞下回及梭状回、缘上叫、顶下小叶、小脑后叶显著被激活（P〈0．05）；含糊奖赏抉择与确定奖赏抉择比较，前额叶额极显著被激活（P〈0．05）；与风险奖赏抉择比较，背外侧前额叶、小脑后叶显著被激活（P〈0．05）。结论不确定性奖赏程度不同，参与加工的脑区存在显著差异。Objective To research the activated brain areas of decision making under uncertainty reward processing on healthy volunteers. Method The E-Prime programs were presented 3 kinds of tasks of the decision under uncertain reward processing. 15 right-handed healthy volunteers made a response after receiving the task. At the same time ,the GE 3.0T magnetic＇, resonance scanner scanned the brains areas of subjects. Individual analysis and group analysis was done with SPM8 software,then the brain activating regions and the peak intensity were gotten. Results Orbitofrontal cortex was activated in certainty, peak intensity 2. 4328 ±0. 1949 （P 〈 0.05 ）. Prefrontal cortex, occipital lobe,parietal lobe,posterior lobe of cerebellum,limbic lobe and midbrain were activated under the risk reward processing,peak intensity 2. 4228± 1. 3762 （P 〈 0.05 ）. When under ambiguity reward processing, prefrontal cortex, temporal lobe, occipital lobe, left inferior frontal gyros and posterior lobe of cerebellum were activated, peak intensity 2. 4056 ± 0. 4222 （P 〈 0.05）. Compared with the task under certainty, posterior lobe of cerebellum, gyri subtemporalis and gyri tusiformis, inferior parietal lobule, anterior central convolution, orbitofrontal cortex,ventrolateral prefrontal cortex,both frontopolar and supramarginal gyras were activated in task under risk （P 〈 0.05 ） ; and both frontopolar were activated in task under ambiguity （P 〈 0.05 ）. Compared with the task under risk, dorsolateral prefrontal cortex and posterior lobe of cerebellum were activated in task under ambiguity （P 〈 0.05 ）. Conclusion There are differences in different types of reward processing of decision making.

关 键 词：抉择 不确定 奖赏 脑 功能磁共振 

分 类 号：R445.2[医药卫生—影像医学与核医学]