慢性阻塞性肺疾病继发性肺动脉高压早期预警的实验室指标研究进展  

Progress of early identification of pulmonary hypertension secondary to chronic obstructive pulmonary diseasewith serum markers

作　　者：谢新明[1] 张永红[1] 王贵佐[1] 李满祥[1] 

机构地区：[1]西安交通大学医学院第二附属医院呼吸病研究室,710004

出　　处：《国际呼吸杂志》2013年第7期543-547,共5页International Journal of Respiration

基　　金：国家自然科学基金（81070045）;2010年卫生部临床重点课题

摘　　要：慢性阻塞性肺疾病（chronicobstructivepulmonarydisease，COPD）是一种气流受限呈不完全可逆、进行性发展的可以预防和治疗的疾病。肺动脉高压是C0PD最常见的并发症之一，其发生机制主要与肺血管收缩及肺血管重塑相关，最终引起肺循环阻力增加，可导致右心衰竭危及生命。COPD继发性肺动脉高压的早期诊断及检测往往容易被忽视，本文就C反应蛋白、B型钠尿肽、中性肽链内切酶、内皮素-1、Apelin、白介素6的水平变化与COPD继发性肺动脉高压的相关性作一综述，以期为COPD继发性肺动脉高压的早期预警提供实验室依据。Chronic obstructive pulmonary disease （COPD） is a preventable and treatable disease, which is characterized with partial reversibility of airflow limitation. Pulmonary hypertension is one of the most common complications of COPD. The mechanisms for the development of pulmonary hypertension in COPD mainly involve the hypoxia-induced pulmonary vascular contraction,and the pulmonary vascular remodeling, leading to elevated resistance of pulmonary circulation, and may further causes right heart failure and death. Early detection and diagnosis of COPD with secondary pulmonary hypertension is often neglected in clinical practice. In this review, we analyzed the correlation between c-reactive protein, b-type natriuretic peptide, neprilysin, endothelin-1, apelin,interleukin-6 and pulmonary hypertension secondary to COPD, to provide sensitive serum markers for early identification of pulmonary hypertension caused by COPD.

关 键 词：慢性阻塞性肺疾病 肺动脉高压 早期预警的实验室指标 

分 类 号：R563.9[医药卫生—呼吸系统]