睡眠呼吸暂停综合征与心血管疾病  

Sleep apnea syndrome and cardiovascular disease

作　　者：林辉煌[1] 曾奕明[1] 

机构地区：[1]福建医科大学附属第二医院呼吸内科,泉州362000

出　　处：《国际呼吸杂志》2013年第7期548-550,共3页International Journal of Respiration

摘　　要：睡眠呼吸暂停综合征是临床上常见的睡眠呼吸疾病。近几年的研究证实睡眠呼吸暂停综合征是心血管疾病的独立危险因素。阻塞型睡眠呼吸暂停综合征的患者在睡眠时由于上呼吸道的阻塞或者部分阻塞而导致机体长期反复的慢性间断性缺氧，而慢性间断性缺氧是阻塞型睡眠呼吸暂停综合征患者发生心血管疾病的主要原因。内皮机能障碍、氧化应激、炎症激活、血脂障碍、凝血障碍、代谢障碍等因素相互作用导致动脉粥样硬化形成从而引起各种心血管疾病。Sleep apnea syndrome is a common clinical sleep respiratory diseases. In recent years, sleep apnea syndrome is confirmed as an independent risk factor for cardiovascular diseases. Due to obstruction or partial obstruction of the upper respiratory tract, patients with obstructive sleep apnea syndrome will happen to the body long-term repeated chronic intermittent hypoxia during sleep. And chronic intermittent hypoxia is the main factor of obstructive sleep apnea syndrome in patients with cardiovascular diseases. Endothelial dysfunction, oxidative stress, inflammatory activation, lipid disorders, coagulation disorders, metabolic disorders, such as the interplay of factors leading to atherosclerosis formation, causing a variety of cardiovascular diseases.

关 键 词：睡眠呼吸暂停综合征 慢性间断性缺氧 心血管疾病 动脉粥样硬化 

分 类 号：R766[医药卫生—耳鼻咽喉科]