正交试验法优选参苓白术颗粒喷雾制粒工艺  

Orthogonal Experiments for Selecting Spraying Granulation Technique of Shenlingbaizhu Granules

作　　者：谷洪燕 

机构地区：[1]攀钢集团成都医院药剂科,四川成都610066

出　　处：《亚太传统医药》2013年第4期40-42,共3页Asia-Pacific Traditional Medicine

摘　　要：目的:通过试验选择参苓白术颗粒喷雾制粒的最佳工艺条件。方法:应用正交试验法。采用喷雾干燥制粒机制粒并在流化床上进行干燥,以浸膏浓缩的相对密度、入塔风温、雾化压力、喷雾液频为考察因素,每个因素3个水平,以成品颗粒的收得率及半成品颗粒的含水量为考察指标。结果:4个因素中以A浸膏相对密度、B入塔风温、C雾化压力的影响较显著(P<0.05)。而D喷雾液频的影响不显著。结论:参苓白术颗粒喷雾制粒的最佳工艺条件为A2B3C2D1。即浸膏相对密度1.10,入塔风温175～180℃,雾化压力0.20MPa,喷雾液频6Hz。Objective： To select the optimum conditions for the spray granulation of Shenlingbaizhu Granules. Methods： The process was studied by orthogonal experiment method. Spray drying granulation mechanism grains and dried on a fluidized bed, tow- er air temperature, the atomization pressure, the spray solution to the relative density of the extract was concentrated, into a fre- quency of the investigated factors, each factor of three levels, to the water content of the yield of the finished particles and semi-par- ticles as index. Results ： The four factors： Arelative density B into the tower air temperature, C atomization pressure more signifi- cantly （P〈0.05）. D spray liquid frequency was not significant. Conclusion：The optimum conditions for the SHENLINGBAISHU particle spray granulation A2 B3 C2 D1. That extract relative density of 1.10, into the tower wind temperature of 175--180℃, atomi- zation pressure 0.20MPa spray liquid frequency 6Hz.

关 键 词：喷雾制粒 制备工艺 正交试验 

分 类 号：R284.2[医药卫生—中药学]