间歇性低氧处理大鼠心肌的抗心律失常与抗氧化效应  

Antiarrhythmic and antioxidative effects of intermittent hypoxia exposure on rat myocardium

作　　者：张翼[1] 钟宁[1] 朱海峰[1] 周兆年[1] 

机构地区：[1]中国科学院上海生理研究所,上海200031

出　　处：《生理学报》2000年第2期89-92,共4页Acta Physiologica Sinica

基　　金：ThisprojectwassupportedbytheNationalNaturalScienceFoundationofChina(No39500052)

摘　　要：利用结扎在体大鼠冠脉方法研究不同时间间歇性低氧处理对缺血、再灌注心律失常以及心肌超氧化物歧化酶 (SOD)、丙二醛 (MDA)的影响 ,并与连续性低氧相比较。实验结果如下 :( 1)间歇性低氧 (intermittenthy poxiaexposure) 2 8d (IH2 8)、42d (IH42 )、间歇性低氧 2 8d后 1周 (PIH2 8 1W)、2周 (PIH2 8 2W )和连续性低氧 (con tinuedhypoxiaexposure) 2 8d (CH2 8)、42d (CH42 )大鼠 ,缺血和再灌注心律失常评分明显低于对照组 ;( 2 )IH2 8、IH42、CH2 8、CH42、PIH2 8 1W、PIH2 8 2W及间歇性低氧 2 8d后 3周 (PIH2 8 3W)大鼠心肌的SOD明显高于对照组 ;而间歇性低氧 14d (IH14)、IH2 8、IH42、CH2 8、CH42、PIH2 8 1W及PIH2 8 2W大鼠心肌的MDA明显低于对照组。实验结果表明 :间歇性低氧处理 2 8d和 42d具有明确的抗缺血和再灌注心律失常作用 ,此作用与心肌抗氧化能力增强有关。抗心律失常作用于间歇性低氧处理 14d后逐渐发生 ,脱离低氧处理后可有效维持The purpose of the study was to observe the effects of intermittent hypoxia exposure (IH) on the arrhythmia and antioxidation with ligation of coronary artery of rat heart together with measuring SOD (superoxide dismutase) and MDA (malondialdehyde) in myocardium. Comparison with continued hypoxia exposure was also made. The results obtained are as follows. (1) Arrhythmia scores of ischemic arrhythmia and reperfusion arrhythmia observed in the rats treated with IH 28 day (IH28) and 42 day (IH42), one week (IH28 1W) and two weeks (IH28 2W) after 28 day IH, as well as in those with continued hypoxia 28 day (CH28) and 42 day (CH42), were significantly lower than controls. (2) SOD in IH28, IH42, CH28, CH42, IH28 1W, IH28 2W and three weeks after 28 day IH were significantly higher than controls; MDA in IH14, IH28, IH42, CH28, CH42, IH28 1W and IH28 2W were significantly lower than controls. It is suggested that IH for 28 or 42 days has some definite antiarrhythmic effect against ischemia and reperfusion, which was related to the strength of antioxidation in myocardium. The antiarrhythmic effects occurred gradually after 14 days IH and persisted for about two weeks after 28 days IH.

关 键 词：间歇性低氧 心律失常 心脏 氧化效应 SOD MAD 

分 类 号：Q463[生物学—生理学] R322.11[医药卫生—人体解剖和组织胚胎学]