SULT1A1基因第7外显子G638A多态性与子宫肌瘤的相关性研究  

The Relationship between SULT1A1 Gene Exon 7 G638A Polymorphism and Uterine Fibroids

作　　者：王春红[1] 王冬梅[2] 冯春梅[3] 高娜[4] 孙志刚[1] 

机构地区：[1]沈阳医学院公共卫生学院,辽宁沈阳110034 [2]中国医科大学法医学院血清学教研室 [3]牡丹江医学院生物技术实验室 [4]大连医科大学附属第一医院妇产科

出　　处：《沈阳医学院学报》2013年第1期21-23,共3页Journal of Shenyang Medical College

基　　金：沈阳医学院青年基金资助项目(No.20112059)

摘　　要：目的:探讨SULT1A1基因第7外显子G638A多态性与子宫肌瘤的相关性。方法:本研究采用PCR-单链构象多态性(single strand conformation polymorphism,PCR-SSCP)结合PCR-DNA测序技术检测SULT1A1基因第7外显子G638A多态性在健康妇女(202例)及子宫肌瘤患者(120例)的分布,统计并推算SULT1A1基因第7外显子G638A与疾病的相关性。结果:SULT1A1基因第7外显子G638A多态性的3个基因型频率及等位基因频率在健康妇女与子宫肌瘤患者间的分布差异有显著性。SULT1A1基因第7外显子G638A多态性与疾病的易感性具有相关性。结论:SULT1A1基因的第7外显子G638A多态性与子宫肌瘤具有相关性,可能是疾病发生的高度易感基因。Objective： To explore the relationship between SULT1A1 gene exon7 G638A polymorphism and uterine fibroids. Methods： PCR-single strand conformation polymorphism （PCR-SSCP） combined PCR-DNA sequencing were used to detect the distribution of SULTIA1 gene exon 7 G638A polymorphism in control （202 healthy women） and uterine fibroids （120 patients）. The results was analyzed and the correlation of SULT1A1 gene exon 7 with uterine fibroids was projected. Results： There were significant differences in SULT1A1 gene exon G638A polymorphism distribution of the three genotypes and allele frequencies between control and patients with uterine fibroids. SULT1A1 gene exon 7 G638A polymorphism and uterine fibroids had significant correlation. Conclusion： SULT1A1 gene exon 7 G638A polymorphism with uterine fibroids correlation may be highly susceptible disease gene.

关 键 词：硫酸基转移酶1A1 单核苷酸多态性 子宫肌瘤 

分 类 号：R711.74[医药卫生—妇产科学]