1,2,4-三嗪酮类衍生物的合成研究及生物活性测试  

Synthesis and Fungicidal Activities of 1,2,4-Triazinone Derivatives

作　　者：张永露[1] 欧阳贵平[1] 贺宝安[1] 吴文能[1] 汤儒平[1] 

机构地区：[1]贵州大学精细化工研究与开发中心,贵阳550025

出　　处：《现代农药》2013年第2期10-13,共4页MODERN AGROCHEMICALS

基　　金：农药新化合物创制研究项目(H110029);贵州大学研究生创新基金项目(2012031)

摘　　要：以5-甲基-1,3,4-二唑-2(3H)-酮为原料,经过烷基化、扩环、水解和酰胺化等4步反应合成了12个新型的1,2,4-三嗪酮类化合物6a～6l,其结构经1H NMR、13C NMR和MS表征。初步生物活性测试结果表明,在50 g/mL质量浓度下,部分目标化合物对小麦赤霉病菌、辣椒枯萎病菌和苹果腐烂病菌表现出一定的生物活性。Using 5-methyl-l,3,4-oxadiazol-2（3H）-one as starting material, twelve novel 1,2,4-triazinone derivatives were synthesized through alkylation, ring-enlargement, hydrolysis and amidation. All title compounds were characterized by 1H NMR, 13C NMR and MS. The preliminary bioassay indicated that some of the compounds exhibited certain fungicidal activities against Gibberella zeae, Fusarium oxysporum and Cytospora mandshurica at a dosage of 50 μg/mL.

关 键 词：1 2 4-三嗪酮类化合物 合成 生物活性测试 

分 类 号：TQ450.1[化学工程—农药化工]