缬沙坦对冠状动脉粥样硬化性心脏病大动脉弹性的影响  

Effect of Valsartan on Large Artery Elasticity in Coronary Atherosclerosis Heart Disease

作　　者：程震锋[1] 韦凡平[1] 陆玉良[1] 李利芳[1] 

机构地区：[1]浙江省湖州市中心医院,浙江湖州313000

出　　处：《中国药业》2013年第6期49-50,共2页China Pharmaceuticals

摘　　要：目的探讨缬沙坦对冠状动脉粥样硬化性心脏病(简称冠心病)患者大动脉弹性的影响。方法将冠心病患者124例随机分为观察组与对照组,各62例,均使用常规药物治疗,观察组加用缬沙坦80 mg/d。在治疗前及治疗6个月后检测患者的踝臂指数(ABI)及臂-踝脉搏波传导速度(ba-PWV)。结果观察组患者的ba-PWV和ABI水平均较治疗前显著改善(P<0.05),对照组均较治疗前无改善(P>0.05);观察组患者中冠状动脉单支病变和双支病变的ba-PWV水平和ABI水平均较治疗前有所改善,差异有统计学意义(P<0.05);观察组患者治疗后发生不良反应2例,对照组有3例,两组不良反应发生率比较差异无统计学意义(χ2=0.208,P=0.648)。结论缬沙坦可以改善冠心病患者的大动脉弹性。Objective To investigate the effect of valsartan on large artery elasticity in coronary atherosclerosis heart disease（CAHD）. Methods A hundred and twenty- four cases of CAHD treated in our hospital were randomly divided into the observation group and the control group,62 cases in each group. The tyro groups were treated by the standardized medication and the observation was added with valsartan 80 mg/d. The ankle brachial index （ABI） and brachial ankle pulse wave velocity （ba-PWV） were respectively detected before treatment and after 6- month treatment. Results The ba- PWV and ABI levels after treatment in the observation group were significantly improved than before treatment（P 〈 0.05）,which in the control group had no improvement （P 〉 0.05）.The ba-PWV level and ABI level of single vessel lesions and double vessel lesions in the observation group were improved somewhat, the difference was statistically significant （P 〈 0. 05）. 2 cases of adverse reactions were found in the observation group and 3 cases of adverse reac- tions were found in the observation group, showing the incidence rate of adverse reactions had no statistical difference between the two groups （X2 =0. 208, P = 0. 648 ）. Conclusion Valsartan can improve the large arterial elasticity in the patients with CAHD.

关 键 词：缬沙坦 冠心病 大动脉弹性 

分 类 号：R969.4[医药卫生—药理学] R972.4[医药卫生—药学]