我院抗菌药物不良反应报告相关因素分析  

Analysis on Related Factors of Antibacterial Drug Adverse Reaction Reports in Our Hospital

作　　者：郑火珺 叶建云[1] 

机构地区：[1]浙江省松阳县人民医院药剂科,浙江丽水323400

出　　处：《中国药业》2013年第6期94-96,共3页China Pharmaceuticals

摘　　要：目的了解医院抗菌药物不良反应发生的特点及规律,为临床合理用药提供参考。方法收集医院124例抗菌药物不良反应报告,从患者情况、不良反应的临床表现、给药途径、抗菌药物种类及因果关系评价等方面进行回顾性统计分析。结果124例抗菌药物不良反应报告中,女性多于男性;以儿童和老年患者居多;引起不良反应的药物以头孢菌素类居首位,共59例,占47.58%。不良反应累及的系统或器官主要是皮肤及其附件29例,占23.39%;消化系统27例,占21.77%;严重及少见不良反应10例,占8.06%。给药途径以静脉滴注最多,共111例,占89.52%。结论加强抗菌药物分级管理,严格掌握用药指征,减少或者避免不良反应的发生。Objective To understand the characteristics and regularity patterns of antibacterial adverse reaction occurrence to provide ref- erence for clinical rational drug use. Methods A hundred and twenty- four cases of antibacterial drug adverse reaction report were collected from this hospital and performed the retrospective statistical analysis in the aspects of the disease condition, clinical manifesta- tions of adverse reactions,routes of administration,types of antibacterial drugs and causal relation. Results Among 124 cases of antibac- terial drug adverse reaction report, women were more than men, children and elderly patients were predominant. The antibacterial drugs causing adverse reactions were cephalosporins topping the list,in 59 cases,accounting for 47.58%. The involved systems and organs by adverse reaction were mainly the skin and accessories in 29 cases（23.39% ）,and the digestive system in 27 cases（21.77% ）. Serious and rare adverse reactions were in 10 cases（8.06% ）. Most of administration route was intravenous drip in 111 case（89.52% ）. Conclusion Strengthening the antibacterial drug classification management, strictly mastering the medication indications can reduce or avoid the occurrence of adverse reactions.

关 键 词：抗菌药物 不良反应 报告分析 

分 类 号：R954[医药卫生—药学] R969.3