补肾方药对绝经后妇女卵巢功能和骨密度的影响  

Effect of kidney-tonifying herbs on ovary function and bone mass in postmenopausal women

作　　者：安胜军[1] 李桃[2] 李恩[1] 

机构地区：[1]河北医科大学中西医结合基础理论研究室,石家庄050017 [2]河北医科大学第三医院河北省骨科研究所

出　　处：《中国骨质疏松杂志》2000年第2期55-59,共5页Chinese Journal of Osteoporosis

摘　　要：本文根据 WHO的骨质疏松诊断标准 ,利用双能 X射线骨密度仪 ,对 2 50例绝经后妇女做骨密度检查 ,筛选出临床诊断为原发性骨质疏松症和骨量减少的妇女 131例 ,在筛选过程中 ,确定肝肾功能正常 ,排除风湿病、肾病、甲旁亢、甲亢、胃癌及胃炎、卵巢摘除等继发性骨质疏松的妇女 ,采用随机双盲对照实验 ,分成 3组 :补肾中药组、依普拉封组、对照组 ,目的是观察补肾中药对原发性骨质疏松症和骨量减少的效果和作用机制 ,并与治疗骨质疏松的西药依普拉封做对照。方法是采用放射免疫分析的方法 ,观察被确定为原发性骨质疏松症和骨量减少的妇女治疗前后血清中卵泡生成素 (FSH)、黄体生成素(LH)、雌二醇 (E2 )的变化 ,同时观察治疗前后的骨密度 (BMD)的变化。结果发现 :补肾中药能明显提高雌激素的水平和增加骨密度 ,与西药相比无任何毒副反应 ,而依普拉封则有不同程度的副反应 (如 :反酸等胃部不适、潮热等 ) ,说明补肾中药是通过整体调节 ,提高体内的雌激素水平 ,提高骨密度 ,其疗效优于西药治疗和雌激素替代治疗的效果。According to the criteria of WHO,131 out of 250 postmenopausal women were diagnosed as having primary osteoporosis by checking the bone mass with dual energy X\|ray densitometer. All selected women had normal function of liver and kidney and no other diseases such as rheumatism,kidney disease,hyperparathyroidism,hyperthyroidism,cancer of stomach,and gastritis. On the basis of double blindness,the patients were divided into three groups: kidney\|tonifying herbs group,ipriflavone group and control group. The purpose was to observe the therapeutic effect and mechanism of kidney\|tonifying herbs on primary osteoporosis. Before and after the treatment,the levels of FSH,LH, and E 2 in serum were determined by the method of RIA and bone mineral density (BMD) was measured. The results showed that kidney\|tonifying herbs increased the levels of E 2 and bone mass,and had no side effects,compared with ipriflavone. This result suggests that kidney\|tonifying herbs increases the bone mass and the level of E 2 by whole body regulation and is superior to ipriflavone.

关 键 词：补肾方药 骨量减少 卵巢功能 骨密度 中药 

分 类 号：R271.05[医药卫生—中医妇科学]