无创性高分辨率超声评价妊高征患者血管内皮功能  

Evaluation of Endothelial Function in Pregnancy-induced Hypertension by Non-invasively High Resolution Ultrasonography

作　　者：袁丽君[1] 段云友[1] 阮骊韬[1] 曹铁生[1] 周玲[1] 

机构地区：[1]第四军医大学唐都医院,陕西西安710038

出　　处：《中国医学影像技术》2000年第8期624-626,共3页Chinese Journal of Medical Imaging Technology

摘　　要：目的　探讨高分辨率超声在妊高征患者血管内皮功能评价中的应用价值。方法　妊高征患者 9例 ,正常妊娠 10例作为对照组。测量肱动脉内径、血流速度 ,计算内径及血流量变化率 (ΔD %、ΔQ % )。结果　妊高征患者的内皮依赖性血管舒张功能较对照组明显减低 (2 0 8%± 2 11%vs 13 0 4%± 3 5 9% ,P <0 0 0 1) ,与临床生化检查中的内皮素和一氧化氮增高相一致 ;内皮非依赖性血管舒张功能妊高征组较对照组亦减低 (14 45 %± 6 73%vs2 5 15 %± 6 98% ,P <0 0 1) ;两组受检者的内皮依赖性血管舒张功能均与收缩压有一定的相关性。ΔQ %在每组中变化较大。结论　妊高征患者的血管内皮依赖及非依赖性舒张功能均有不同程度的损害 ,高分辨率超声可无创。Purpose To evaluate endothelial function of patients with pregnancy-induced hypertension (PIH) by ultrasonography. Methods We measured the diameter of the brachial artery and recorded its blood flow spectrum with two-dimensional and Doppler echocardiography in 9 PIH patients and 10 normal pregnant (NP) women.The endothelium-dependent and endothelium-independent dilatations (EDD,EID) were calculated separately. Results EDD was much less in patients with PIH than in NP group (2 08%±2 11% vs 13 04%±3 59%, P <0 001),so was the response to nitroglycerin (NTG) in this study (14 45%±6 73% vs 25 15%±6 98%, P <0 01).EDD impairment corresponded with the elevation of serum endothelin and NO - 2/NO - 3.There existed positive correlation between the EDD and the systolic pressure to a certain degree in both of the two groups.The quantity of blood flow varied greatly among the patients. Conclusion This study demonstrated that both the EDD and EID were impaired in some degree in PIH patients.Ultrasonography is a non-invasive and an accurate method to detect both the EDD and EID of pregnant women. [

关 键 词：内皮功能 妊高征 高分辨率超声 

分 类 号：R714.246[医药卫生—妇产科学]