磷脂酰乙醇胺结合蛋白的信号调节机制及其生物学功能研究进展  

Roles of phosphatidylethanolamine-binding protein in cell signaling and its biological functions

作　　者：边佳明[1] 吴宁[2] 李锦[2] 

机构地区：[1]北京军区总医院药理科,北京100700 [2]军事医学科学院毒物药物研究所,北京100850

出　　处：《生理学报》2013年第2期237-243,共7页Acta Physiologica Sinica

基　　金：supported by the National Basic Research Development Program of China(No.2009CB522008);the National Natural Science Foundation of China(No.30772563);Beijing Municipal Natural Science Foundation;China(No.7082075)

摘　　要：磷脂酰乙醇胺结合蛋白(phosphatidylethanolamine-binding protein,PEBP)是一个结构上高度保守的胞浆可溶性蛋白。近年的研究显示,在细胞信号转导中,PEBP具有多种生物学功能,包括调节ERK通路、NF-κB通路、G蛋白偶联受体通路等多种重要的信号转导。此外,PEBP在肿瘤领域的临床研究价值也得到了越来越多的支持和认可,其表达水平和多种肿瘤的转移相关。作为一个多功能的信号调节分子,PEBP正在成为多个领域的研究热点。本文就近年来有关PEBP信号调节机制和生物学功能的研究进展做一回顾。Phosphatidylethanolamine-binding protein （PEBP） is a cytoplasm soluble protein with a high conserved structure. It has been approved recently that PEBP is a multifunctional molecule regulating several important cellular signal pathways, including ERK cascade, NF-r,B pathway, and signaling of G protein-coupled receptors. Furthermore, the role of PEBP in tumor metastasis also got a comprehensive attention in the field of clinical cancer research. Together, as a signal regulator at multiple paths in cell, PEBP is becoming a new focus in several research fields. This review is aimed to introduce the newest biological progress on PEBP.

关 键 词：磷脂酰乙醇胺结合蛋白 RAF激酶抑制蛋白 ERK NF-ΚB 海马 

分 类 号：Q954.434[生物学—动物学]