卵子线粒体老化——辅助生殖技术面临的瓶颈  

Oocyte Mitochondiral Aging——Bottleneck of Assisted Reproductive Technology(ART)

作　　者：汤江静[1] 尹萍[1] 邵敬於[1] 段涛[1] 滕晓明[1] 韩毅冰[1] 

机构地区：[1]同济大学附属上海市第一妇婴保健院,上海200040

出　　处：《生殖与避孕》2013年第4期255-260,共6页Reproduction and Contraception

摘　　要：卵子老化是辅助生殖失败的一个重要原因。目前,许多妇女生育年龄不断推迟,导致卵子老化问题日益严重。线粒体是细胞中提供能量的重要细胞器,体细胞衰老与线粒体功能异常密切相关。由于线粒体是卵子/胚胎中数量最多的细胞器,推测线粒体功能的损伤可能在卵子老化、受精成功率和体外胚胎发育方面,也起到重要作用。本文根据前人的研究成果,阐述了线粒体在卵子成熟、受精以及胚胎发育过程中的作用,分析了线粒体老化对卵子质量和受精胚胎发育的影响,证明提高卵母细胞中线粒体功能,对提高卵母细胞/体外受精胚胎的质量具有重要的意义。＂Oocyte aging＂ is an important cause for IVF failure and poor embryo quality. At present, many women delay their pregnancy to the later part of their childbearing years which makes ＂oocyte aging＂ a more important etiology for infertility. Mitochondrial dysfunction is associated with somatic cells senescence. Because mitochondria are the most abundant organelles in oocytes/embryos, we speculate that mitochondrial dysfunction may have an important role in oocyte maturation, fertilization and embryo development too. In this article, we have reviewed the function ofmitochondria during oocyte maturation, fertilization and the following embryo development. Techniques improving mitochondrial function in the oocytes could not only prevent the oocyte aging process, but also improve the quality of embryos from assisted reproductive technology （ART）.

关 键 词：线粒体 卵子老化 辅助生殖 

分 类 号：R714.8[医药卫生—妇产科学]