β2糖蛋白Ⅰ在生殖过程中的作用及机制研究进展  

Research Advances in the Roles and Mechanisms of β2-glycoprotein Ⅰ in Reproduction and Development

作　　者：王薇[1] 张学红[1] 

机构地区：[1]兰州大学第一医院生殖医学研究中心,兰州730000

出　　处：《生殖与避孕》2013年第4期266-271,共6页Reproduction and Contraception

摘　　要：β2糖蛋白Ⅰ(β2GPⅠ)系血浆中富含的一种由326个氨基酸残基组成的高度糖基化蛋白,包含5个结构域,具有优先结合带负电荷磷脂类的特性。β2糖蛋白Ⅰ参与脂代谢,是多种脂蛋白的组成成分;参与血液凝固过程,具有抗凝和促凝双重活性。近年研究表明,β2糖蛋白Ⅰ作为一种生理性蛋白在生物生殖发育中发挥着重要的作用,能够提高精子活力,清除凋亡小体,对精子的生成和颗粒细胞增殖具有调节作用,与妊娠结局密切相关。Beta 2-glycoprotein I （βGP I） is a highly glycosylated plasma protein comprised of 326 amino acids, contains 5 structural domains, with the ability to preferentially bind negatively charged phospholipids. β2GP I is involved in lipoprotein metabolism, it is the component of various lipoproteins. In addition, it is also involved in blood coagulation processes, With the dual activity of anticoagulation and pro-coagulation. Recent studies have suggested that β2GP I as a physiological protein plays an important role in reproduction and development. It has the ability to stimulate sperm motility, clear apoptotic bodies, regulate the spermatogenesis and mitotic proliferation of granulosa cells, thus it is related with pregnancy outcomes closely.

关 键 词：β2糖蛋白I(β2GP I) 生殖 发育 研究进展 

分 类 号：R339.2[医药卫生—人体生理学]