臭氧联合中药治疗中老年阳虚寒湿型膝骨性关节炎临床观察  

Treatment of Middle-aged and Aged Patients with Knee Osteoarthritis of Yang-deficiency Induced Cold-damp Syndrome by Ozone Combined Chinese Materia Medica: a Clinical Research

作　　者：李娟红[1] 周立霞[1] 李桂英[1] 程斌[1] 

机构地区：[1]北京老年医院疼痛科,北京100095

出　　处：《中国中西医结合杂志》2013年第4期471-475,共5页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察臭氧联合中药治疗中老年阳虚寒湿型膝关节骨性关节炎患者的临床疗效。方法采用前瞻性、随机对照试验的设计,200例膝骨性关节炎患者分为4组:对照组口服扶他林片;中医组口服附桂骨痛颗粒;臭氧组实施膝关节腔注射臭氧(25mg/L)10～18mL,每周1次,共4周;结合组实施膝关节腔注射臭氧治疗同时服用附桂骨痛颗粒,疗程均为1个月。使用视觉模拟评分法(VAS)、西部安大略麦克马斯特大学骨关节炎指数可视化量表(Western Ontario MacMaster University Osteoarthritis index,WOMAC)评价疗效。结果治疗后24h及1周,结合组VAS评分明显低于同期中医组和对照组(P<0.05);治疗1个月,结合组VAS评分明显低于同期对照组、中医组和臭氧组(P<0.05)。治疗后WOMAC总积分结合组为(25.34±2.12)分,明显低于对照组(44.72±6.57)分、中医组(40.58±5.98)分和臭氧组(38.53±5.13)分,差异均有统计学意义(P<0.05);结合组疼痛评分、关节僵硬积分和日常活动积分均低于对照组(P<0.05);结合组总愈显率(76.0%)高于对照组(25.0%)、中医组(25.0%)和臭氧组(43.8%),差异均有统计学意义(P<0.05)。结论臭氧联合中药治疗中老年阳虚寒湿型膝关节骨性关节炎在缓解关节疼痛、改善关节僵硬及日常活动方面具有优势。Objective To observe the clinical efficacy of treating middle-aged and aged patients with knee osteoarthritis （KOA） of yang-deficiency induced cold-damp syndrome （YDICDS） by ozone combined Fugui Gutong Granule （FGG）. Methods Using a prospective, randomized controlled clinical trial, 200 KOA patients of YDICDS were randomly assigned to four groups. i.e., the control group （Group A）, the Chinese medicine treatment group （Group B）, the ozone group （Group C）, and the Chinese medicine treatment plus ozone group （Group D）. Patients in Group A took Voltaren Tablet. Those in Group B took FGG. Those in Group C received ozone injection （10-18 mL） from knee joint cavity at 25 mg/L, once weekly for 4 weeks in total. Those in Group D received injection from knee joint cavity and took FGG. The therapeutic course for all was one month. The efficacy was assessed using visual analogue scale （VAS） and Western Ontario MacMaster University Osteoarthritis index （WOMAC）. Results The VAS score was obviously lower in Group D than in Group B and Group A at 24 h and 1 week （P0.05）. After one month of treatment, the VAS score was obviously lower in Group D than in Group A, B, and C （P0.05）. After treatment the total integral of WOMAC was 25.34±2.12 in Group D, obviously lower than that in Group A （44.72±6.57）, Group B （40.58±5.98）, and Group C （38.53±5.13）, showing statistical difference （P0.05）. The pain score, the joint stiffness score, the score for daily activities were lower in Group D than in Group A （P0.05）. The cured and markedly effective rate was 76.0% in Group D, higher than that of Group A （25.0%）, Group B （25.0%）, and Group C （43.8%）, respectively （P0.05）. Conclusion Ozone combined FGG had advantages in alleviating joint pain, and improving joint stiffness and daily activities of middle-aged and aged patients with KOA of YDICDS.

关 键 词：膝骨性关节炎 臭氧 中药 中老年 阳虚寒湿型 

分 类 号：R274[医药卫生—中医骨伤科学]