荆花胃康胶丸预防非甾体类消炎药相关性小肠损伤的实验研究  

Preventive Effects of Jinghua Weikang Capsule on NSAID-induced Injury to the Mucosa of the Small Intestine: an Experimental Research

作　　者：丁瑞峰[1] 郭元虎[1] 韩文鹏 王爱鱼[1] 谢立平[3] 赵鹏程[1] 

机构地区：[1]内蒙古包头医学院第一附属医院消化科,内蒙古包头014010 [2]山东青岛市城阳区人民医院,山东青岛266109 [3]内蒙古包头医学院第一附属医院病理科,内蒙古包头014010

出　　处：《中国中西医结合杂志》2013年第4期522-525,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：内蒙古自治区自然科学基金项目(No.2011MS1173)

摘　　要：目的研究荆花胃康胶丸是否对双氯芬酸灌胃给药建立非甾体类消炎药(non-steroidal anti-in-flammatory drugs,NSAIDs)相关性小肠损伤模型有保护作用。方法 Wistar大鼠32只随机分为4组:空白对照组、模型组、荆花胃康胶丸组和埃索美拉唑组。模型组和两个治疗组均给予双氯芬酸[15mg/(kg·d)],两个治疗组提前1天分别给予荆花胃康胶丸和埃索美拉唑。空白对照组给予生理盐水,3天后处死大鼠,取小肠组织行HE染色观察病理改变。结果与空白对照组比较,模型组大鼠小肠大体评分(4.63±0.52)及组织病理评分(4.00±0.90)明显增高(P<0.05);与模型组比较,荆花胃康组大鼠小肠大体评分(1.88±0.99)及组织病理评分(2.11±1.11)明显降低,差异有统计学意义(P<0.05);与模型组比较,埃索美拉唑组大鼠小肠大体评分(2.75±1.28)及组织病理评分(2.30±0.94)明显降低,差异有统计学意义(P<0.05)。结论荆花胃康胶丸可以预防NSAIDs相关性小肠损伤。Objective To study the preventive effects of Jinghua Weikang Capsule （JWC） on non-steroidal anti-inflammatory drugs （NSAIDs） induced injury to the mucosa of the small intestine. Methods Thirty-two Wistar rats were randomly divided into four groups, i.e., the blank control group, the model group, the JWC group, and the esomeprazole group. Diclofenac was administered to rats in the model group, the JWC group, and the esomeprazole group at the daily dose of 15 mg/kg. JWC and esomeprazole was respectively given to those in the JWC group, and the esomeprazole group one day ahead. Normal saline was given to rats in the blank control group. Rats were killed 3 days later. The pathological changes of the small intestine were observed by hematoxylin and eosin stain. Results Compared with the blank control group, the general score for the small intestine （4.63±0.52 vs 0.00±0.00） and the pathological score （4.00±0.90 vs 0.00±0.00） obviously increased in the model group, showing statistical difference （P0.05）. Compared with the model group, the general score for the small intestine （1.88±0.99） and the pathological score （2.11±1.11） obviously decreased in the JWG group, showing statistical difference （P0.05）. Compared with the model group, the general score for the small intestine （2.75±1.28） and the pathological score （2.30±0.94） obviously decreased in the esomeprazole group, showing statistical difference （P0.05）. Conclusion JWC could prevent NSAIDs induced injury to the mucosa of the small intestine.

关 键 词：小肠损伤 非甾体类消炎药 荆花胃康胶丸 

分 类 号：R259[医药卫生—中西医结合]