心肺交互作用综合测试系统  

Comprehensive Testing System for Cardiorespiratory Interaction Research

作　　者：张政波[1] 王步青[1] 王卫东[1] 郑捷文[2] 刘洪运[1] 李开元[1] 孙聪聪[3] 王国静[4] 

机构地区：[1]解放军总医院医学工程保障中心,北京100853 [2]军事医学科学院卫生装备研究所,天津300162 [3]北京理工大学信息与电子学院,北京100081 [4]解放军总医院军医进修学院,北京100853

出　　处：《生物医学工程学杂志》2013年第2期395-402,共8页Journal of Biomedical Engineering

基　　金：国家自然科学基金青年基金资助项目(60801009);国家自然科学基金资助项目(60971044);北京市自然科学基金资助项目(3102028;3122034)

摘　　要：为研究呼吸与心血管系统参量间的关系及其调节作用,研发了心肺交互作用综合测试系统。系统由生理参数检测单元、数据采集和医用电气隔离单元、上位机软件控制单元三部分组成,可在不同的数据采集协议下同步采集呼吸流量、胸腹呼吸、心电、脉搏、心音、皮温、肌电等多道生理参数,研究不同呼吸模式下的短时心血管变异性。试验结果表明,该系统能够准确描记调息过程中的胸腹呼吸运动,采用直流耦合模式的呼吸感应体积描记技术能够在低频节律性呼吸过程中准确记录呼吸运动曲线,而且校准后能够实现不佩戴口鼻面罩情况下的潮气量测量,从而最大限度地降低受试者身心负荷;呼吸引导模块能够根据需要产生音/视频的呼吸运动引导信号,引导受试者进行渐进性低频节律性呼吸;多例健康志愿者试验表明,该系统能够有效引导调息运动,并同步采集引导呼吸过程中的各类生理参数。信号处理技术能够实现无创潮气量校准、QRS波检测、RR间期提取、呼吸性窦性心律不齐(RSA)计算、脉搏波传导时间(PWTT)计算等功能,初步的试验数据分析表明,在渐进性低频节律性呼吸过程中,呼吸运动对RR间期、RSA、PWTT等心血管参数起到越来越强的调制作用。To investigate the modulation effects of breathing movement on cardiovascular system and to study the physiological coupling relationship between respiration and cardiovascular system, we designed a comprehensive tes- ting system for cardiorespiratory interaction research. This system, comprising three parts, i.e. physiological signal conditioning unit, data acquisition and USB medical isolation unit, and a PC based program, can acquire multiple physiological data such as respiratory flow, rib cage and abdomen movement, electrocardiograph, artery pulse wave, cardiac sounds, skin temperature, and electromyography simultaneously under certain experimental protocols. Fur- thermore this system can be used in research on short-term cardiovascular variability by paced breathing. Preliminary experiments showed that this system could accurately record rib cage and abdomen movement under very low breath- ing rate, using respiratory inductive plethysmography to acquire respiration signal in direct-current coupling mode.After calibration, gram can generate this system can be used to estimate ventilation non-intrusively and correctly. The PC based pro- audio and visual biofeedback signal, and guide the volunteers to perform a slow and regular breath- ing. An experiment on healthy volunteers showed that this system was able to guide the volunteers to do slow breathing effectively and simultaneously record multiple physiological data during the experiments. Signal processing techniques were used for off-line data analysis, such as non-invasive ventilation calibration, QRS complex wave de- tection, and respiratory sinus arrhythmia and pulse wave transit time calculation. The experiment result showed that the modulation effect on RR interval, respiratory sinus arrhythmia （RSA）, pulse wave transit time （PWTT） by res- piration would get stronger with the going of the slow and regular breathing.

关 键 词：心肺交互作用 引导呼吸 呼吸感应体积描记 呼吸性窦性心律不齐 脉搏波传导时间 

分 类 号：R318.6[医药卫生—生物医学工程]