针刺郄门穴对心肌缺血大鼠作用及相关机制的实验研究  

The experimental study on the effect and relative mechanism of acupuncture at Ximen(PC4) on the cardiodynamics in the Myocardial Ischemia Model of Rats

作　　者：蒋莉娅[1] 黄继人 诸静芬[3] 戴建良 张卫东[3] 

机构地区：[1]无锡市第二人民医院中医科,江苏无锡214002 [2]无锡市中西医结合医院心内科,江苏无锡214041 [3]无锡市中医院心内科,江苏无锡214001

出　　处：《中国中医基础医学杂志》2013年第4期439-442,共4页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：目的:探讨针刺郄门穴改善大鼠心肌缺血的作用机制。方法:制备心肌缺血模型,观察针刺郄门及合谷穴后的各组指标变化。结果:针刺治疗后,郄门和合谷组心脏动力学指标均改善(P<0.01),两者血浆NO均高于模型组(P<0.01或P<0.05),心肌细胞中Bcl-2/Bax比值升高(P<0.01),且郄门组改善均较合谷组显著(P<0.05)。结论:针刺郄门穴可改善心脏动力学指标,增加血浆NO释放,并通过调节Bcl-2和Bax表达,抑制心肌细胞凋亡,从而改善心肌缺血、保护心肌细胞。Objective ： To investigate the effect and relative mechanism of acupuncture at Ximen （PC4） on myocardial ischemia. Methods： After the models of myocardial ischemia made, the Ximen group and Hegu（LI4） group were separately pinpricked at Ximen or Hegu additionally. Then all the indexes were observed. Results： Compared with the model group, the cardiodynamics parameters of the Ximen and Hegu group were improved （P 〈 0.01 ）. The contents of NO the Ximen and Hegu group were significantly increased than that of model group （ P 〈0. 01 or P 〈 0.05 ）. The ratios of Bcl-2 in to Bax were upregulated in Ximen and Hegu group （ P 〈 0.01 ）. All the indexes of Ximen group were improved then Hegn group（P 〈0.05）. Conclusion： Acupuncuting at Ximen can improve myocardial ischemia by improving the cardiodynamics parameters, increasing NO release and inhibiting apoptosis of cardiac muscle cell.

关 键 词：郄门穴 针刺 心脏动力学 一氧化氮 合谷穴 凋亡 

分 类 号：R245.31[医药卫生—针灸推拿学]